Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5735599..5736194 Replicon chromosome
Accession NZ_CP044006
Organism Pseudomonas aeruginosa strain E90

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FVA82_RS27665 Protein ID WP_071536079.1
Coordinates 5735916..5736194 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FVA82_RS27660 Protein ID WP_003099268.1
Coordinates 5735599..5735904 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA82_RS27625 5731577..5732155 - 579 Protein_5321 DNA cytosine methyltransferase -
FVA82_RS27630 5732163..5732450 - 288 WP_031689773.1 DUF5447 family protein -
FVA82_RS27635 5732626..5732898 - 273 WP_004352675.1 hypothetical protein -
FVA82_RS27640 5733008..5733274 + 267 WP_023088595.1 hypothetical protein -
FVA82_RS27645 5733330..5733665 + 336 WP_031689774.1 hypothetical protein -
FVA82_RS27650 5733718..5734809 + 1092 WP_124132249.1 hypothetical protein -
FVA82_RS27655 5734870..5735262 - 393 WP_049951329.1 hypothetical protein -
FVA82_RS27660 5735599..5735904 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
FVA82_RS27665 5735916..5736194 - 279 WP_071536079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVA82_RS27675 5736523..5738751 + 2229 WP_031689776.1 TonB-dependent receptor -
FVA82_RS27680 5738821..5739468 - 648 WP_003095021.1 carbonate dehydratase -
FVA82_RS27685 5739530..5740768 - 1239 WP_017001387.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10632.17 Da        Isoelectric Point: 7.8937

>T139872 WP_071536079.1 NZ_CP044006:c5736194-5735916 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T139872 NZ_CP058839:3491360-3491533 [Shigella flexneri]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT139872 WP_003099268.1 NZ_CP044006:c5735904-5735599 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT139872 NZ_CP058839:3491036-3491332 [Shigella flexneri]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References