Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
Location | 5735599..5736194 | Replicon | chromosome |
Accession | NZ_CP044006 | ||
Organism | Pseudomonas aeruginosa strain E90 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | FVA82_RS27665 | Protein ID | WP_071536079.1 |
Coordinates | 5735916..5736194 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | FVA82_RS27660 | Protein ID | WP_003099268.1 |
Coordinates | 5735599..5735904 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FVA82_RS27625 | 5731577..5732155 | - | 579 | Protein_5321 | DNA cytosine methyltransferase | - |
FVA82_RS27630 | 5732163..5732450 | - | 288 | WP_031689773.1 | DUF5447 family protein | - |
FVA82_RS27635 | 5732626..5732898 | - | 273 | WP_004352675.1 | hypothetical protein | - |
FVA82_RS27640 | 5733008..5733274 | + | 267 | WP_023088595.1 | hypothetical protein | - |
FVA82_RS27645 | 5733330..5733665 | + | 336 | WP_031689774.1 | hypothetical protein | - |
FVA82_RS27650 | 5733718..5734809 | + | 1092 | WP_124132249.1 | hypothetical protein | - |
FVA82_RS27655 | 5734870..5735262 | - | 393 | WP_049951329.1 | hypothetical protein | - |
FVA82_RS27660 | 5735599..5735904 | - | 306 | WP_003099268.1 | HigA family addiction module antidote protein | Antitoxin |
FVA82_RS27665 | 5735916..5736194 | - | 279 | WP_071536079.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FVA82_RS27675 | 5736523..5738751 | + | 2229 | WP_031689776.1 | TonB-dependent receptor | - |
FVA82_RS27680 | 5738821..5739468 | - | 648 | WP_003095021.1 | carbonate dehydratase | - |
FVA82_RS27685 | 5739530..5740768 | - | 1239 | WP_017001387.1 | C69 family dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10632.17 Da Isoelectric Point: 7.8937
>T139872 WP_071536079.1 NZ_CP044006:c5736194-5735916 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T139872 NZ_CP058839:3491360-3491533 [Shigella flexneri]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 102 a.a. Molecular weight: 11213.79 Da Isoelectric Point: 5.0747
>AT139872 WP_003099268.1 NZ_CP044006:c5735904-5735599 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
Download Length: 306 bp
>AT139872 NZ_CP058839:3491036-3491332 [Shigella flexneri]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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