Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2189591..2190459 | Replicon | chromosome |
| Accession | NZ_CP043997 | ||
| Organism | Mycobacterium tuberculosis strain 1-0066P6C4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | FPJ49_RS10120 | Protein ID | WP_010886136.1 |
| Coordinates | 2189591..2189968 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | FPJ49_RS10125 | Protein ID | WP_003409886.1 |
| Coordinates | 2190010..2190459 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPJ49_RS10070 | 2185380..2185832 | - | 453 | WP_003899095.1 | lipoprotein | - |
| FPJ49_RS10075 | 2185896..2186297 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| FPJ49_RS10080 | 2186290..2186472 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| FPJ49_RS10085 | 2186586..2186936 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FPJ49_RS10090 | 2186947..2187849 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FPJ49_RS10095 | 2187870..2188061 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FPJ49_RS10100 | 2188062..2188358 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FPJ49_RS10105 | 2188598..2188813 | + | 216 | WP_003409878.1 | antitoxin | - |
| FPJ49_RS10110 | 2188810..2189121 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ49_RS10115 | 2189095..2189616 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FPJ49_RS10120 | 2189591..2189968 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| FPJ49_RS10125 | 2190010..2190459 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| FPJ49_RS10130 | 2190456..2191001 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPJ49_RS10135 | 2190890..2191504 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FPJ49_RS10140 | 2191553..2191849 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FPJ49_RS10145 | 2191846..2192097 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FPJ49_RS10150 | 2192084..2192578 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FPJ49_RS10155 | 2192738..2193145 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPJ49_RS10160 | 2193149..2193421 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPJ49_RS10165 | 2193454..2194674 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T139837 WP_010886136.1 NZ_CP043997:2189591-2189968 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T139837 NZ_CP058833:c716626-716339 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT139837 WP_003409886.1 NZ_CP043997:2190010-2190459 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT139837 NZ_CP058833:c716865-716626 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|