Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975876..2976524 Replicon chromosome
Accession NZ_CP043996
Organism Mycobacterium tuberculosis strain 1-0072P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ52_RS13900 Protein ID WP_003899414.1
Coordinates 2975876..2976199 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ52_RS13905 Protein ID WP_003899415.1
Coordinates 2976279..2976524 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ52_RS13870 2971199..2972197 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ52_RS13875 2972211..2972675 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ52_RS13880 2972663..2972914 + 252 WP_003908028.1 hypothetical protein -
FPJ52_RS13885 2973085..2974524 - 1440 WP_003901443.1 phage major capsid protein -
FPJ52_RS13890 2974532..2975065 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ52_RS13895 2975218..2975709 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ52_RS13900 2975876..2976199 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ52_RS13905 2976279..2976524 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ52_RS13910 2976521..2977948 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ52_RS13915 2977950..2978342 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ52_RS13920 2978339..2978599 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ52_RS13925 2978616..2978978 - 363 WP_003900543.1 hypothetical protein -
FPJ52_RS13930 2978981..2980108 - 1128 WP_003899420.1 site-specific integrase -
FPJ52_RS13935 2980253..2980480 - 228 WP_003899421.1 hypothetical protein -
FPJ52_RS13940 2980477..2980866 - 390 WP_003899422.1 hypothetical protein -
FPJ52_RS13945 2980772..2981044 + 273 WP_003900544.1 hypothetical protein -
FPJ52_RS13950 2981143..2981376 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2971199..2980108 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T139793 WP_003899414.1 NZ_CP043996:c2976199-2975876 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T139793 NZ_CP058828:755177-755473 [Shigella flexneri]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT139793 WP_003899415.1 NZ_CP043996:c2976524-2976279 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT139793 NZ_CP058828:755475-755870 [Shigella flexneri]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References