Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 867304..867824 Replicon chromosome
Accession NZ_CP043962
Organism Agrobacterium fabrum strain BG5

Toxin (Protein)


Gene name yoeB Uniprot ID A9CID9
Locus tag F3P66_RS03985 Protein ID WP_010972002.1
Coordinates 867555..867824 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q7CY23
Locus tag F3P66_RS03980 Protein ID WP_010972003.1
Coordinates 867304..867558 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3P66_RS03960 862906..863952 - 1047 WP_006311839.1 NAD(P)-dependent alcohol dehydrogenase -
F3P66_RS03965 864142..865047 + 906 WP_010972005.1 AraC family transcriptional regulator -
F3P66_RS03970 865446..866099 + 654 WP_006311841.1 TetR/AcrR family transcriptional regulator -
F3P66_RS03975 866147..867166 + 1020 WP_010972004.1 ketol-acid reductoisomerase -
F3P66_RS03980 867304..867558 + 255 WP_010972003.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F3P66_RS03985 867555..867824 + 270 WP_010972002.1 Txe/YoeB family addiction module toxin Toxin
F3P66_RS03990 867829..868278 - 450 WP_010972001.1 RbsD/FucU family protein -
F3P66_RS03995 868553..869796 + 1244 Protein_787 PLP-dependent aminotransferase family protein -
F3P66_RS04000 870103..871086 + 984 WP_010971999.1 ABC transporter substrate-binding protein -
F3P66_RS04005 871096..872790 + 1695 WP_010971998.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10612.09 Da        Isoelectric Point: 9.8742

>T139679 WP_010972002.1 NZ_CP043962:867555-867824 [Agrobacterium fabrum]
MKLVWTLSSWDDYEFWQRTDARMVEKINDLIRNAKRTPFAGLGKPEPLKGDMAGYWSRRITAEHRFVYRVSGSGSEQRLE
VIQCRFHYQ

Download         Length: 270 bp

>T139679 NZ_CP058780:611517-611831 [Shigella flexneri]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTAGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9577.70 Da        Isoelectric Point: 4.6749

>AT139679 WP_010972003.1 NZ_CP043962:867304-867558 [Agrobacterium fabrum]
MANVRFTEFRQNFATHFDRVLETRAPLLVTRQGKEAVVVLAEGEYESMQETLHLLSNPANASRLRASMGELERGDTIERD
PTEE

Download         Length: 255 bp

>AT139679 NZ_CP058780:611828-612244 [Shigella flexneri]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6N90

Antitoxin

Source ID Structure
AlphaFold DB Q7CY23

References