Detailed information of TA system TA139654

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4921554..4921776
• Replicon: chromosome
• Accession: NZ_CP043950
• Organism: Escherichia coli strain ST95-32

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: F3J96_RS24515
• Protein ID: WP_001295224.1
• Coordinates: 4921554..4921661 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4921718..4921776 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3J96_RS24490	4916808..4917560	-	753	WP_000279545.1	cellulose biosynthesis protein BcsQ	-
F3J96_RS24495	4917572..4917760	-	189	WP_001063314.1	YhjR family protein	-
F3J96_RS24500	4918033..4919604	+	1572	WP_001204957.1	cellulose biosynthesis protein BcsE	-
F3J96_RS24505	4919601..4919792	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
F3J96_RS24510	4919789..4921468	+	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
F3J96_RS24515	4921554..4921661	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4921718..4921776	+	59	-	-	Antitoxin
F3J96_RS24520	4922036..4922143	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
F3J96_RS24530	4922518..4922625	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
F3J96_RS24540	4923000..4923107	-	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	-
F3J96_RS24550	4923583..4924854	+	1272	WP_001332306.1	amino acid permease	-
F3J96_RS24555	4924884..4925888	-	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T139654 WP_001295224.1 NZ_CP043950:c4921661-4921554 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T139654 NZ_CP058771:934585-934992 [Shigella flexneri]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT139654 NZ_CP043950:4921718-4921776 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin