139650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3142705..3143207 Replicon chromosome
Accession NZ_CP043950
Organism Escherichia coli strain ST95-32

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag F3J96_RS15820 Protein ID WP_000767822.1
Coordinates 3142705..3142959 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag F3J96_RS15825 Protein ID WP_001259255.1
Coordinates 3142956..3143207 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3J96_RS15800 3139198..3140556 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
F3J96_RS15805 3140546..3140608 - 63 WP_010723108.1 membrane protein YoeI -
F3J96_RS15810 3140823..3141752 - 930 WP_000803366.1 LysR family transcriptional regulator -
F3J96_RS15815 3141798..3142622 - 825 WP_000754733.1 SDR family oxidoreductase -
F3J96_RS15820 3142705..3142959 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
F3J96_RS15825 3142956..3143207 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
F3J96_RS15830 3143490..3143540 + 51 WP_001364200.1 his operon leader peptide -
F3J96_RS15835 3143686..3144585 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
F3J96_RS15840 3144591..3145895 + 1305 WP_001617113.1 histidinol dehydrogenase -
F3J96_RS15845 3145892..3146962 + 1071 WP_150330661.1 histidinol-phosphate transaminase -
F3J96_RS15850 3146962..3148029 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T139650 WP_000767822.1 NZ_CP043950:c3142959-3142705 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T139650 NZ_CP058771:266853-266960 [Shigella flexneri]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT139650 WP_001259255.1 NZ_CP043950:c3143207-3142956 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT139650 NZ_CP058771:c266805-266739 [Shigella flexneri]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References