Detailed information of TA system TA139633

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2338348..2338573
• Replicon: chromosome
• Accession: NZ_CP043950
• Organism: Escherichia coli strain ST95-32

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A8S7B7V6
• Locus tag: F3J96_RS11660
• Protein ID: WP_000813256.1
• Coordinates: 2338418..2338573 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2338348..2338406 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3J96_RS11620	2333373..2333615	+	243	WP_000747951.1	hypothetical protein	-
F3J96_RS11625	2333599..2334024	+	426	WP_000693867.1	Rha family transcriptional regulator	-
F3J96_RS11630	2334096..2335166	+	1071	WP_001262357.1	hypothetical protein	-
F3J96_RS11635	2335207..2335629	+	423	WP_001151216.1	DUF977 family protein	-
F3J96_RS11640	2335821..2336783	+	963	WP_014639476.1	hypothetical protein	-
F3J96_RS11645	2336799..2337800	+	1002	WP_000354966.1	hypothetical protein	-
-	2338348..2338406	-	59	-	-	Antitoxin
F3J96_RS11660	2338418..2338573	+	156	WP_000813256.1	type I toxin-antitoxin system toxin HokD	Toxin
F3J96_RS11665	2338741..2339019	+	279	WP_011478175.1	hypothetical protein	-
F3J96_RS11670	2339021..2340067	+	1047	WP_001265108.1	DUF968 domain-containing protein	-
F3J96_RS11675	2340080..2340454	+	375	WP_000904114.1	RusA family crossover junction endodeoxyribonuclease	-
F3J96_RS11680	2340451..2341272	+	822	WP_000762880.1	antitermination protein	-
F3J96_RS11685	2341497..2341694	+	198	WP_000917749.1	hypothetical protein	-
F3J96_RS11690	2341845..2342894	+	1050	WP_000935515.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2322755..2372361	49606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5764.94 Da
• Isoelectric Point: 6.1531

>T139633 WP_000813256.1 NZ_CP043950:2338418-2338573 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTVYEPEE

Nucleotide

• Length: 156 bp

>T139633 NZ_CP058758:333174-333521 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT139633 NZ_CP043950:c2338406-2338348 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin