Detailed information of TA system TA139629

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2282800..2283021
• Replicon: chromosome
• Accession: NZ_CP043950
• Organism: Escherichia coli strain ST95-32

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1PGT3
• Locus tag: F3J96_RS11355
• Protein ID: WP_000170954.1
• Coordinates: 2282800..2282907 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2282960..2283021 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F3J96_RS11330	2278645..2279727	+	1083	WP_000804726.1	peptide chain release factor 1	-
F3J96_RS11335	2279727..2280560	+	834	WP_000456474.1	peptide chain release factor N(5)-glutamine methyltransferase	-
F3J96_RS11340	2280557..2280949	+	393	WP_000200375.1	invasion regulator SirB2	-
F3J96_RS11345	2280953..2281762	+	810	WP_001257054.1	invasion regulator SirB1	-
F3J96_RS11350	2281798..2282652	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
F3J96_RS11355	2282800..2282907	-	108	WP_000170954.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2282960..2283021	+	62	NuclAT_14	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_14	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_14	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_14	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_15	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_15	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_15	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_15	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_16	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_16	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_16	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_16	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_17	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_17	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_17	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_17	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_18	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_18	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_18	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_18	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_19	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_19	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_19	-	Antitoxin
-	2282960..2283021	+	62	NuclAT_19	-	Antitoxin
-	2282960..2283022	+	63	NuclAT_10	-	-
-	2282960..2283022	+	63	NuclAT_10	-	-
-	2282960..2283022	+	63	NuclAT_10	-	-
-	2282960..2283022	+	63	NuclAT_10	-	-
-	2282960..2283022	+	63	NuclAT_11	-	-
-	2282960..2283022	+	63	NuclAT_11	-	-
-	2282960..2283022	+	63	NuclAT_11	-	-
-	2282960..2283022	+	63	NuclAT_11	-	-
-	2282960..2283022	+	63	NuclAT_12	-	-
-	2282960..2283022	+	63	NuclAT_12	-	-
-	2282960..2283022	+	63	NuclAT_12	-	-
-	2282960..2283022	+	63	NuclAT_12	-	-
-	2282960..2283022	+	63	NuclAT_13	-	-
-	2282960..2283022	+	63	NuclAT_13	-	-
-	2282960..2283022	+	63	NuclAT_13	-	-
-	2282960..2283022	+	63	NuclAT_13	-	-
-	2282960..2283022	+	63	NuclAT_8	-	-
-	2282960..2283022	+	63	NuclAT_8	-	-
-	2282960..2283022	+	63	NuclAT_8	-	-
-	2282960..2283022	+	63	NuclAT_8	-	-
-	2282960..2283022	+	63	NuclAT_9	-	-
-	2282960..2283022	+	63	NuclAT_9	-	-
-	2282960..2283022	+	63	NuclAT_9	-	-
-	2282960..2283022	+	63	NuclAT_9	-	-
-	2282960..2283023	+	64	NuclAT_20	-	-
-	2282960..2283023	+	64	NuclAT_20	-	-
-	2282960..2283023	+	64	NuclAT_20	-	-
-	2282960..2283023	+	64	NuclAT_20	-	-
-	2282960..2283023	+	64	NuclAT_21	-	-
-	2282960..2283023	+	64	NuclAT_21	-	-
-	2282960..2283023	+	64	NuclAT_21	-	-
-	2282960..2283023	+	64	NuclAT_21	-	-
-	2282960..2283023	+	64	NuclAT_22	-	-
-	2282960..2283023	+	64	NuclAT_22	-	-
-	2282960..2283023	+	64	NuclAT_22	-	-
-	2282960..2283023	+	64	NuclAT_22	-	-
-	2282960..2283023	+	64	NuclAT_23	-	-
-	2282960..2283023	+	64	NuclAT_23	-	-
-	2282960..2283023	+	64	NuclAT_23	-	-
-	2282960..2283023	+	64	NuclAT_23	-	-
-	2282960..2283023	+	64	NuclAT_24	-	-
-	2282960..2283023	+	64	NuclAT_24	-	-
-	2282960..2283023	+	64	NuclAT_24	-	-
-	2282960..2283023	+	64	NuclAT_24	-	-
-	2282960..2283023	+	64	NuclAT_25	-	-
-	2282960..2283023	+	64	NuclAT_25	-	-
-	2282960..2283023	+	64	NuclAT_25	-	-
-	2282960..2283023	+	64	NuclAT_25	-	-
F3J96_RS11365	2283313..2284413	-	1101	WP_001313768.1	sodium-potassium/proton antiporter ChaA	-
F3J96_RS11370	2284683..2284913	+	231	WP_001146444.1	putative cation transport regulator ChaB	-
F3J96_RS11375	2285071..2285766	+	696	WP_000632706.1	glutathione-specific gamma-glutamylcyclotransferase	-
F3J96_RS11380	2285810..2286163	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-
F3J96_RS11385	2286348..2287742	+	1395	WP_000086194.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3983.80 Da
• Isoelectric Point: 11.4779

>T139629 WP_000170954.1 NZ_CP043950:c2282907-2282800 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T139629 NZ_CP058753:40053-40535 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCAGTTCTACGTTGTTATCGCGTAGCTGAGAATATTGGTGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Nucleotide

• Length: 62 bp

>AT139629 NZ_CP043950:2282960-2283021 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7U9LPE9

Antitoxin