139579

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 721534..722227 Replicon chromosome
Accession NZ_CP043946
Organism Escherichia coli strain AR202.2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag F3P13_RS03515 Protein ID WP_000415584.1
Coordinates 721534..721830 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag F3P13_RS03520 Protein ID WP_000650107.1
Coordinates 721832..722227 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F3P13_RS03480 716622..716936 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
F3P13_RS03485 716967..717548 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
F3P13_RS03490 717867..718199 + 333 WP_000917685.1 DUF2645 family protein -
F3P13_RS03495 718245..719594 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
F3P13_RS03500 719591..720250 - 660 WP_001221493.1 two-component system response regulator QseB -
F3P13_RS03505 720402..720794 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
F3P13_RS03510 720847..721329 + 483 WP_000183505.1 transcriptional regulator -
F3P13_RS03515 721534..721830 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
F3P13_RS03520 721832..722227 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
F3P13_RS03525 722360..723967 + 1608 WP_087523553.1 ABC transporter substrate-binding protein -
F3P13_RS03530 724105..726363 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T139579 WP_000415584.1 NZ_CP043946:721534-721830 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T139579 NZ_CP058743:4034485-4034703 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT139579 WP_000650107.1 NZ_CP043946:721832-722227 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT139579 NZ_CP058743:4034084-4034458 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References