Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1374308..1374529 Replicon chromosome
Accession NZ_CP043937
Organism Escherichia coli strain RM14516

Toxin (Protein)


Gene name ldrD Uniprot ID A0A229AEQ8
Locus tag FS841_RS06505 Protein ID WP_000176713.1
Coordinates 1374308..1374415 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1374463..1374529 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS841_RS06480 (1370153) 1370153..1371235 + 1083 WP_000804726.1 peptide chain release factor 1 -
FS841_RS06485 (1371235) 1371235..1372068 + 834 WP_000456458.1 peptide chain release factor N(5)-glutamine methyltransferase -
FS841_RS06490 (1372065) 1372065..1372457 + 393 WP_000151883.1 invasion regulator SirB2 -
FS841_RS06495 (1372461) 1372461..1373270 + 810 WP_001257044.1 invasion regulator SirB1 -
FS841_RS06500 (1373306) 1373306..1374160 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
FS841_RS06505 (1374308) 1374308..1374415 - 108 WP_000176713.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (1374465) 1374465..1374528 + 64 NuclAT_27 - -
- (1374465) 1374465..1374528 + 64 NuclAT_27 - -
- (1374465) 1374465..1374528 + 64 NuclAT_27 - -
- (1374465) 1374465..1374528 + 64 NuclAT_27 - -
- (1374465) 1374465..1374528 + 64 NuclAT_29 - -
- (1374465) 1374465..1374528 + 64 NuclAT_29 - -
- (1374465) 1374465..1374528 + 64 NuclAT_29 - -
- (1374465) 1374465..1374528 + 64 NuclAT_29 - -
- (1374465) 1374465..1374528 + 64 NuclAT_31 - -
- (1374465) 1374465..1374528 + 64 NuclAT_31 - -
- (1374465) 1374465..1374528 + 64 NuclAT_31 - -
- (1374465) 1374465..1374528 + 64 NuclAT_31 - -
- (1374465) 1374465..1374528 + 64 NuclAT_33 - -
- (1374465) 1374465..1374528 + 64 NuclAT_33 - -
- (1374465) 1374465..1374528 + 64 NuclAT_33 - -
- (1374465) 1374465..1374528 + 64 NuclAT_33 - -
- (1374465) 1374465..1374528 + 64 NuclAT_35 - -
- (1374465) 1374465..1374528 + 64 NuclAT_35 - -
- (1374465) 1374465..1374528 + 64 NuclAT_35 - -
- (1374465) 1374465..1374528 + 64 NuclAT_35 - -
- (1374465) 1374465..1374528 + 64 NuclAT_37 - -
- (1374465) 1374465..1374528 + 64 NuclAT_37 - -
- (1374465) 1374465..1374528 + 64 NuclAT_37 - -
- (1374465) 1374465..1374528 + 64 NuclAT_37 - -
- (1374463) 1374463..1374529 + 67 NuclAT_14 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_14 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_14 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_14 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_16 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_16 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_16 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_16 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_18 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_18 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_18 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_18 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_20 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_20 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_20 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_20 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_22 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_22 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_22 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_22 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_24 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_24 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_24 - Antitoxin
- (1374463) 1374463..1374529 + 67 NuclAT_24 - Antitoxin
- (1374465) 1374465..1374530 + 66 NuclAT_39 - -
- (1374465) 1374465..1374530 + 66 NuclAT_39 - -
- (1374465) 1374465..1374530 + 66 NuclAT_39 - -
- (1374465) 1374465..1374530 + 66 NuclAT_39 - -
- (1374465) 1374465..1374530 + 66 NuclAT_41 - -
- (1374465) 1374465..1374530 + 66 NuclAT_41 - -
- (1374465) 1374465..1374530 + 66 NuclAT_41 - -
- (1374465) 1374465..1374530 + 66 NuclAT_41 - -
- (1374465) 1374465..1374530 + 66 NuclAT_43 - -
- (1374465) 1374465..1374530 + 66 NuclAT_43 - -
- (1374465) 1374465..1374530 + 66 NuclAT_43 - -
- (1374465) 1374465..1374530 + 66 NuclAT_43 - -
FS841_RS06510 (1374843) 1374843..1374950 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein -
- (1375003) 1375003..1375064 + 62 NuclAT_26 - -
- (1375003) 1375003..1375064 + 62 NuclAT_26 - -
- (1375003) 1375003..1375064 + 62 NuclAT_26 - -
- (1375003) 1375003..1375064 + 62 NuclAT_26 - -
- (1375003) 1375003..1375064 + 62 NuclAT_28 - -
- (1375003) 1375003..1375064 + 62 NuclAT_28 - -
- (1375003) 1375003..1375064 + 62 NuclAT_28 - -
- (1375003) 1375003..1375064 + 62 NuclAT_28 - -
- (1375003) 1375003..1375064 + 62 NuclAT_30 - -
- (1375003) 1375003..1375064 + 62 NuclAT_30 - -
- (1375003) 1375003..1375064 + 62 NuclAT_30 - -
- (1375003) 1375003..1375064 + 62 NuclAT_30 - -
- (1375003) 1375003..1375064 + 62 NuclAT_32 - -
- (1375003) 1375003..1375064 + 62 NuclAT_32 - -
- (1375003) 1375003..1375064 + 62 NuclAT_32 - -
- (1375003) 1375003..1375064 + 62 NuclAT_32 - -
- (1375003) 1375003..1375064 + 62 NuclAT_34 - -
- (1375003) 1375003..1375064 + 62 NuclAT_34 - -
- (1375003) 1375003..1375064 + 62 NuclAT_34 - -
- (1375003) 1375003..1375064 + 62 NuclAT_34 - -
- (1375003) 1375003..1375064 + 62 NuclAT_36 - -
- (1375003) 1375003..1375064 + 62 NuclAT_36 - -
- (1375003) 1375003..1375064 + 62 NuclAT_36 - -
- (1375003) 1375003..1375064 + 62 NuclAT_36 - -
- (1375003) 1375003..1375065 + 63 NuclAT_15 - -
- (1375003) 1375003..1375065 + 63 NuclAT_15 - -
- (1375003) 1375003..1375065 + 63 NuclAT_15 - -
- (1375003) 1375003..1375065 + 63 NuclAT_15 - -
- (1375003) 1375003..1375065 + 63 NuclAT_17 - -
- (1375003) 1375003..1375065 + 63 NuclAT_17 - -
- (1375003) 1375003..1375065 + 63 NuclAT_17 - -
- (1375003) 1375003..1375065 + 63 NuclAT_17 - -
- (1375003) 1375003..1375065 + 63 NuclAT_19 - -
- (1375003) 1375003..1375065 + 63 NuclAT_19 - -
- (1375003) 1375003..1375065 + 63 NuclAT_19 - -
- (1375003) 1375003..1375065 + 63 NuclAT_19 - -
- (1375003) 1375003..1375065 + 63 NuclAT_21 - -
- (1375003) 1375003..1375065 + 63 NuclAT_21 - -
- (1375003) 1375003..1375065 + 63 NuclAT_21 - -
- (1375003) 1375003..1375065 + 63 NuclAT_21 - -
- (1375003) 1375003..1375065 + 63 NuclAT_23 - -
- (1375003) 1375003..1375065 + 63 NuclAT_23 - -
- (1375003) 1375003..1375065 + 63 NuclAT_23 - -
- (1375003) 1375003..1375065 + 63 NuclAT_23 - -
- (1375003) 1375003..1375065 + 63 NuclAT_25 - -
- (1375003) 1375003..1375065 + 63 NuclAT_25 - -
- (1375003) 1375003..1375065 + 63 NuclAT_25 - -
- (1375003) 1375003..1375065 + 63 NuclAT_25 - -
- (1375003) 1375003..1375066 + 64 NuclAT_38 - -
- (1375003) 1375003..1375066 + 64 NuclAT_38 - -
- (1375003) 1375003..1375066 + 64 NuclAT_38 - -
- (1375003) 1375003..1375066 + 64 NuclAT_38 - -
- (1375003) 1375003..1375066 + 64 NuclAT_40 - -
- (1375003) 1375003..1375066 + 64 NuclAT_40 - -
- (1375003) 1375003..1375066 + 64 NuclAT_40 - -
- (1375003) 1375003..1375066 + 64 NuclAT_40 - -
- (1375003) 1375003..1375066 + 64 NuclAT_42 - -
- (1375003) 1375003..1375066 + 64 NuclAT_42 - -
- (1375003) 1375003..1375066 + 64 NuclAT_42 - -
- (1375003) 1375003..1375066 + 64 NuclAT_42 - -
FS841_RS06515 (1375356) 1375356..1376456 - 1101 WP_001309461.1 sodium-potassium/proton antiporter ChaA -
FS841_RS06520 (1376726) 1376726..1376956 + 231 WP_001146450.1 putative cation transport regulator ChaB -
FS841_RS06525 (1377114) 1377114..1377809 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
FS841_RS06530 (1377853) 1377853..1378206 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4031.79 Da        Isoelectric Point: 11.4779

>T139513 WP_000176713.1 NZ_CP043937:c1374415-1374308 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T139513 NZ_CP058719:c117121-116786 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 67 bp

>AT139513 NZ_CP043937:1374463-1374529 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229AEQ8

Antitoxin

Download structure file

References