Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 15400..15658 Replicon chromosome
Accession NZ_CP043937
Organism Escherichia coli strain RM14516

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FS841_RS00075 Protein ID WP_000809168.1
Coordinates 15400..15552 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15601..15658 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS841_RS00055 10642..11355 - 714 WP_001102367.1 acidic protein MsyB -
FS841_RS00060 11381..11785 - 405 WP_000843584.1 DUF2541 family protein -
FS841_RS00065 12161..14077 + 1917 WP_000516135.1 molecular chaperone DnaK -
FS841_RS00070 14166..15296 + 1131 WP_001118464.1 molecular chaperone DnaJ -
FS841_RS00075 15400..15552 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15601..15658 + 58 - - Antitoxin
FS841_RS00080 16138..17304 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
FS841_RS00085 17370..18269 + 900 WP_001300855.1 transcriptional activator NhaR -
FS841_RS00090 18307..19266 - 960 WP_000871674.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-47)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T139508 WP_000809168.1 NZ_CP043937:c15552-15400 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T139508 NZ_CP058715:82276-82554 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCTTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 58 bp

>AT139508 NZ_CP043937:15601-15658 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1NX00


Antitoxin

Download structure file

References