139465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 857447..858777 Replicon chromosome
Accession NZ_CP043925
Organism Proteus columbae strain T60

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag F1325_RS03955 Protein ID WP_160230024.1
Coordinates 857447..858469 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag F1325_RS03960 Protein ID WP_109371556.1
Coordinates 858466..858777 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1325_RS03945 852504..854936 + 2433 WP_109372065.1 ATP-dependent helicase HrpB -
F1325_RS03950 855080..857386 + 2307 WP_109371560.1 bifunctional glycosyl transferase/transpeptidase -
F1325_RS03955 857447..858469 - 1023 WP_160230024.1 HipA domain-containing protein Toxin
F1325_RS03960 858466..858777 - 312 WP_109371556.1 HipA N-terminal domain-containing protein Antitoxin
F1325_RS03965 858762..859112 - 351 WP_109371554.1 transcriptional regulator -
F1325_RS03970 859495..860781 - 1287 WP_109371552.1 glutamate-1-semialdehyde 2,1-aminomutase -
F1325_RS03975 861057..861401 + 345 WP_006534944.1 iron-sulfur cluster insertion protein ErpA -
F1325_RS03980 861670..862497 - 828 WP_109371550.1 vitamin B12 ABC transporter substrate-binding protein BtuF -
F1325_RS03985 862602..863297 - 696 WP_109371548.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38790.60 Da        Isoelectric Point: 6.1023

>T139465 WP_160230024.1 NZ_CP043925:c858469-857447 [Proteus columbae]
MNLQHCLINLNKLQGSELDSGYSLLGIKSLFSNKDMILNLPFTRSQFIQELPERQKGMSISGYQPKLSLYVKDNILQVIN
NNGTYILKPSPEEYPYLAENEHATMMVMQRLKFSIPPFGLFRFKQEDGKPEEFAFVIKRYDRIGSDAVRLHQEQLDGAMG
INDKYGLSEGKKAVSYESAAKYLITNVNNSLKSKRDIFLRIVYAYVLGNNDYHLRNMGIILPDNAPPSLAPVYDFVSVVP
YPSAFTEYLALPLLALEENDIDTAPGLNSKYGEYIGFDFILLAEHIDINLKLAQKWLGDIINSHQLIIDTYNESHMPEEH
RELVLAYVARRINLLKITTL

Download         Length: 1023 bp

>T139465 NZ_CP058691:c101567-101268 [Paracoccus pantotrophus]
ATGGCGCGATATGACGTTTATGCCAGCCCGGATGGTTCGGGGTATCTTCTCGATGTGCAGACCGACCTTCTGGACAATCT
GAGCACGCGCCTTGTGGTGCCGATGATGCCGGTGGGCGCTTCGCCGCCCGTGCTCAAGCAGCTGAACCCCATCTTTGACA
TACAGTCCGAGCGCTATGTGATGGTGACGCAGTTCATGGCCGCGGTTCCCGCTTCCATTCTGAAGACACTCGCAGGCAGC
CTTGCACAGCACGATACCGAGATCACGGGCGCGCTGGACATGCTCCTGACCGGGGTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12093.90 Da        Isoelectric Point: 5.6573

>AT139465 WP_109371556.1 NZ_CP043925:c858777-858466 [Proteus columbae]
MPRKIEVWLYEKPAGVLSEEENGFIFHYYDNYTGRAISLSMPVRTEHYWSEELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMKNGNDLLGAVVLKEITL

Download         Length: 312 bp

>AT139465 NZ_CP043925:c858777-858466 [Proteus columbae]
ATGCCTCGAAAAATAGAAGTCTGGCTTTATGAAAAGCCTGCTGGTGTTTTAAGTGAAGAAGAAAATGGGTTTATTTTTCA
CTATTATGATAACTACACAGGCAGAGCAATATCTTTAAGTATGCCTGTTAGAACAGAGCATTATTGGAGTGAAGAATTAC
ACCCTTTTTTTAAAGGGCTAGCACCAGAAGGATGGTTACGTAAACGTTACTCTGAAATTCAAAAAATTGATGATAAAGAT
TTGTTTGGTCTATTAATGAAAAATGGTAATGACTTATTAGGGGCTGTTGTACTTAAAGAGATAACTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References