Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13321..13979 | Replicon | plasmid pSX2_LC6 |
| Accession | NZ_CP043904 | ||
| Organism | Shewanella sp. LC6 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | D3VM97 |
| Locus tag | FJD32_RS24390 | Protein ID | WP_013141682.1 |
| Coordinates | 13629..13979 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FJD32_RS24385 | Protein ID | WP_140907106.1 |
| Coordinates | 13321..13623 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FJD32_RS24330 | 8499..8927 | + | 429 | WP_140907117.1 | hypothetical protein | - |
| FJD32_RS24335 | 8984..9349 | + | 366 | WP_140907116.1 | hypothetical protein | - |
| FJD32_RS24340 | 9343..9789 | + | 447 | WP_140907115.1 | Fe3+-siderophore ABC transporter permease | - |
| FJD32_RS24345 | 9786..10304 | + | 519 | WP_140907114.1 | nitrite reductase | - |
| FJD32_RS24350 | 10304..10534 | + | 231 | WP_140907113.1 | hypothetical protein | - |
| FJD32_RS24355 | 10521..11378 | + | 858 | WP_140907112.1 | hypothetical protein | - |
| FJD32_RS24360 | 11290..11592 | + | 303 | WP_181159841.1 | hypothetical protein | - |
| FJD32_RS24365 | 11608..12135 | + | 528 | WP_140907110.1 | thermonuclease family protein | - |
| FJD32_RS24370 | 12203..12628 | + | 426 | WP_140907109.1 | ATP-binding protein | - |
| FJD32_RS24375 | 12638..12910 | + | 273 | WP_140907108.1 | HU family DNA-binding protein | - |
| FJD32_RS24380 | 12999..13292 | + | 294 | WP_140907107.1 | chromosome segregation protein ParM | - |
| FJD32_RS24385 | 13321..13623 | - | 303 | WP_140907106.1 | XRE family transcriptional regulator | Antitoxin |
| FJD32_RS24390 | 13629..13979 | - | 351 | WP_013141682.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FJD32_RS24395 | 14419..14613 | + | 195 | WP_140907105.1 | hypothetical protein | - |
| FJD32_RS24400 | 14624..14998 | + | 375 | WP_140907104.1 | hypothetical protein | - |
| FJD32_RS24405 | 15081..15422 | + | 342 | WP_140907103.1 | hypothetical protein | - |
| FJD32_RS24410 | 15440..15796 | - | 357 | WP_140907102.1 | hypothetical protein | - |
| FJD32_RS24415 | 15893..16390 | + | 498 | WP_181159831.1 | DUF1643 domain-containing protein | - |
| FJD32_RS24420 | 16436..17113 | - | 678 | WP_140907101.1 | hypothetical protein | - |
| FJD32_RS24425 | 17666..18598 | + | 933 | WP_140907099.1 | hypothetical protein | - |
| FJD32_RS24430 | 18659..18829 | + | 171 | Protein_30 | chromosome partitioning protein ParB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..119324 | 119324 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13300.16 Da Isoelectric Point: 5.2421
>T139455 WP_013141682.1 NZ_CP043904:c13979-13629 [Shewanella sp. LC6]
MWAIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPLRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWAIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPLRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T139455 NZ_CP058682:c5501144-5500833 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 10920.66 Da Isoelectric Point: 9.5936
>AT139455 WP_140907106.1 NZ_CP043904:c13623-13321 [Shewanella sp. LC6]
MARTLDQMLATEKPDVVAKAQKAATEMLLNIHLAELRSRVKLTQGEIAASLGVKQPTVSDMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFSV
MARTLDQMLATEKPDVVAKAQKAATEMLLNIHLAELRSRVKLTQGEIAASLGVKQPTVSDMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFSV
Download Length: 303 bp
>AT139455 NZ_CP058682:c5500832-5500542 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|