Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4365247..4365922 Replicon chromosome
Accession NZ_CP043853
Organism Enterobacter hormaechei strain EB_P6_L3_02.19

Toxin (Protein)


Gene name higB Uniprot ID A0A7T9SGM4
Locus tag F1867_RS21295 Protein ID WP_032654718.1
Coordinates 4365623..4365922 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag F1867_RS21290 Protein ID WP_015571639.1
Coordinates 4365247..4365612 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1867_RS21270 4360941..4362320 + 1380 WP_045911566.1 amidohydrolase family protein -
F1867_RS21275 4362431..4363033 - 603 WP_017382759.1 short chain dehydrogenase -
F1867_RS21280 4363131..4364018 + 888 WP_015571641.1 LysR family transcriptional regulator -
F1867_RS21285 4364039..4365220 + 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
F1867_RS21290 4365247..4365612 - 366 WP_015571639.1 HigA family addiction module antidote protein Antitoxin
F1867_RS21295 4365623..4365922 - 300 WP_032654718.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1867_RS21300 4366173..4367333 - 1161 WP_085929677.1 HlyD family efflux transporter periplasmic adaptor subunit -
F1867_RS21305 4367353..4369544 - 2192 Protein_4104 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11582.25 Da        Isoelectric Point: 9.8425

>T139415 WP_032654718.1 NZ_CP043853:c4365922-4365623 [Enterobacter hormaechei]
MINHYRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SAGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T139415 NZ_CP058671:c112780-112253 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCATGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGACACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAAAGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCTGCTTTAGCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT139415 WP_015571639.1 NZ_CP043853:c4365612-4365247 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp

>AT139415 NZ_CP058671:c113067-112777 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9SGM4

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References