Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1926369..1927096 Replicon chromosome
Accession NZ_CP043853
Organism Enterobacter hormaechei strain EB_P6_L3_02.19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F1867_RS09415 Protein ID WP_045910678.1
Coordinates 1926369..1926680 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F1867_RS09420 Protein ID WP_045910679.1
Coordinates 1926677..1927096 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1867_RS09390 1922348..1923127 - 780 WP_028012263.1 acetolactate decarboxylase -
F1867_RS09395 1923233..1924114 + 882 WP_003858850.1 LysR family transcriptional regulator -
F1867_RS09400 1924417..1924524 + 108 WP_157843337.1 ash family protein -
F1867_RS09405 1924551..1925006 + 456 WP_045910676.1 hypothetical protein -
F1867_RS09410 1925248..1926030 + 783 WP_045910677.1 DUF2971 domain-containing protein -
F1867_RS09415 1926369..1926680 + 312 WP_045910678.1 type II toxin-antitoxin system HigB family toxin Toxin
F1867_RS09420 1926677..1927096 + 420 WP_045910679.1 helix-turn-helix domain-containing protein Antitoxin
F1867_RS09425 1927149..1928039 - 891 WP_045910680.1 oxidoreductase -
F1867_RS09430 1928145..1929266 + 1122 WP_015571201.1 glutamate--cysteine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12464.32 Da        Isoelectric Point: 10.0947

>T139410 WP_045910678.1 NZ_CP043853:1926369-1926680 [Enterobacter hormaechei]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPGDMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHADYDKLMDYYRRTKE

Download         Length: 312 bp

>T139410 NZ_CP058669:521753-522004 [Hyphobacterium sp. CCMP332]
ATGCGGTCGGTGAGTTACACGAAATCCGCGTTGAAAGTGTTGCGGAAGATGTCGCGGCCGGATGCTTTGCGAATTATGGC
GGAAGTCGACCAGTTCGCTATTGATCCGGAGAGTCTGGCCAACAATGTGAAGCGGCTGCAGGGAAGCGACTTCATCCGCC
TTCGCGTCGGAGACTGGCGCGTGATCATGGATGATCAGGGCGCTGTTCTGGCGGTCATCAGGATCGGACCGCGTGGCAGC
GTTTACGAATAG

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15389.48 Da        Isoelectric Point: 4.7238

>AT139410 WP_045910679.1 NZ_CP043853:1926677-1927096 [Enterobacter hormaechei]
MNYAAAIKAANALTNALPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp

>AT139410 NZ_CP058669:522014-522370 [Hyphobacterium sp. CCMP332]
ATGCAGACGATCAACACCCCGGATGGCGGCATCATGGTGATGCTGGCTCTGGAAGAATACCAAGCCCTGGTCGATGCCGC
CGATATCGCTGAAGGTCACCGCATCAGACAGCGCCTGGCCTCCGGCGAGGAGGAATTGCTGCCATCAGATATGGTCCGGC
GGCTCGTCGCCGGGGAGACGCCGCTCCGGGTCTGGCGGAAATATCGCGGCATTTCTGCGGCGGACCTGGCCCGTCAGGCT
CATCTCAGCCGGGCCTATATCAGCCAGATCGAGACCGGAAAGCGCCAGCCCGGCGTCGCGGCCTTGCGCCGGATCGCCAC
AGTTCTGAACGCCGATCTTGATGATCTGGTGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References