Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 5365..5878 Replicon plasmid unnamed
Accession NZ_CP043848
Organism Staphylococcus epidermidis strain NCCP 16828

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F1614_RS12240 Protein ID WP_002456261.1
Coordinates 5612..5878 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A8B5RQB4
Locus tag F1614_RS12235 Protein ID WP_002452575.1
Coordinates 5365..5619 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1614_RS12215 841..2110 + 1270 Protein_1 D-alanyl-D-alanine carboxypeptidase -
F1614_RS12220 2545..3195 - 651 Protein_2 CPBP family intramembrane metalloprotease -
F1614_RS12615 3563..3733 - 171 WP_002456306.1 hypothetical protein -
F1614_RS12230 5098..5295 - 198 WP_080395233.1 plasmid recombination protein -
F1614_RS12235 5365..5619 + 255 WP_002452575.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F1614_RS12240 5612..5878 + 267 WP_002456261.1 Txe/YoeB family addiction module toxin Toxin
F1614_RS12245 6501..7049 - 549 WP_158171990.1 recombinase family protein -
F1614_RS12250 7363..7719 + 357 WP_002441965.1 hypothetical protein -
F1614_RS12620 8183..8590 - 408 Protein_9 cellulase family glycosylhydrolase -
F1614_RS12260 8617..8961 - 345 WP_127133369.1 hypothetical protein -
F1614_RS12265 9214..10485 - 1272 WP_017464873.1 cellulase family glycosylhydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..54321 54321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10492.15 Da        Isoelectric Point: 10.1215

>T139368 WP_002456261.1 NZ_CP043848:5612-5878 [Staphylococcus epidermidis]
MNKYNVTFTPTAFEDYKYWQTQDKKLLKKINSLIKSIQRNGILEGEGKPEPLKGNLKGYYSRRINHEHRLVYTIKDPSII
IIACRYHY

Download         Length: 267 bp

>T139368 NZ_CP058657:c29408-29256 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9651.68 Da        Isoelectric Point: 4.1237

>AT139368 WP_002452575.1 NZ_CP043848:5365-5619 [Staphylococcus epidermidis]
MTVLTYSNARKDFRKLIDKVNDDSDTVTITTNDRNAVLISEDDYNSIMETLYLQQSPVNAKRLAQSMEEAERVNTVEVDI
TTYE

Download         Length: 255 bp

>AT139368 NZ_CP058657:29460-29520 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A8B5RQB4

References