Detailed information of TA system TA139357

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 863013..863351
• Replicon: chromosome
• Accession: NZ_CP043843
• Organism: Staphylococcus aureus strain NCCP 16830

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: F1612_RS04370
• Protein ID: WP_011447039.1
• Coordinates: 863013..863189 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	863177..863351 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1612_RS04350	858248..862033	+	3786	WP_158172965.1	hypothetical protein	-
F1612_RS04355	862023..862175	+	153	WP_001153681.1	hypothetical protein	-
F1612_RS04360	862222..862509	+	288	WP_001040261.1	hypothetical protein	-
F1612_RS04365	862567..862863	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
F1612_RS04370	863013..863189	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	863177..863351	-	175	-	-	Antitoxin
F1612_RS04380	863401..863655	+	255	WP_000611512.1	phage holin	-
F1612_RS04385	863667..864422	+	756	WP_000861038.1	CHAP domain-containing protein	-
F1612_RS04390	864612..865103	+	492	WP_000919350.1	staphylokinase	-
F1612_RS04395	865752..866087	+	336	Protein_859	SH3 domain-containing protein	-
F1612_RS04400	866182..866631	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
F1612_RS04405	867317..867667	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
F1612_RS04410	867720..867980	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	813362..867667	54305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T139357 WP_011447039.1 NZ_CP043843:863013-863189 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T139357 NZ_CP058656:902260-902667 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT139357 NZ_CP043843:c863351-863177 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin