Detailed information of TA system TA139352

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 689625..689904
• Replicon: chromosome
• Accession: NZ_CP043843
• Organism: Staphylococcus aureus strain NCCP 16830

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: F1612_RS03385
• Protein ID: WP_001802298.1
• Coordinates: 689625..689729 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	689725..689904 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1612_RS03360	685010..685792	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
F1612_RS03365	685860..686717	+	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
F1612_RS03370	687412..687513	-	102	WP_045173434.1	hypothetical protein	-
F1612_RS03375	687802..688938	+	1137	WP_158172952.1	SAP domain-containing protein	-
F1612_RS03380	688981..689464	+	484	Protein_661	recombinase family protein	-
F1612_RS03385	689625..689729	+	105	WP_001802298.1	hypothetical protein	Toxin
-	689725..689904	-	180	-	-	Antitoxin
F1612_RS03390	690167..691258	-	1092	WP_000495671.1	lytic regulatory protein	-
F1612_RS03395	691524..692501	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
F1612_RS03400	692503..692823	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
F1612_RS03405	692975..693640	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T139352 WP_001802298.1 NZ_CP043843:689625-689729 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T139352 NZ_CP058654:31280-31582 [Escherichia coli]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT139352 NZ_CP043843:c689904-689725 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin