Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 405177..405361 Replicon chromosome
Accession NZ_CP043843
Organism Staphylococcus aureus strain NCCP 16830

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag F1612_RS01895 Protein ID WP_000482647.1
Coordinates 405177..405284 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 405301..405361 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1612_RS01870 400539..401012 + 474 WP_000456489.1 GyrI-like domain-containing protein -
F1612_RS01875 401135..402346 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
F1612_RS01880 402528..403187 - 660 WP_000831298.1 membrane protein -
F1612_RS01885 403247..404389 - 1143 WP_001176863.1 glycerate kinase -
F1612_RS01890 404657..405043 + 387 WP_000779360.1 flippase GtxA -
F1612_RS01895 405177..405284 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 405301..405361 - 61 - - Antitoxin
F1612_RS01900 405932..407695 + 1764 WP_045172654.1 ABC transporter ATP-binding protein/permease -
F1612_RS01905 407720..409453 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
F1612_RS01910 409684..409851 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T139348 WP_000482647.1 NZ_CP043843:405177-405284 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T139348 NZ_CP058652:c29408-29256 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 61 bp

>AT139348 NZ_CP043843:c405361-405301 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References