Detailed information of TA system TA139347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 372302..372825
• Replicon: chromosome
• Accession: NZ_CP043843
• Organism: Staphylococcus aureus strain NCCP 16830

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: F1612_RS01750
• Protein ID: WP_000074043.1
• Coordinates: 372559..372825 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: F1612_RS01745
• Protein ID: WP_000587618.1
• Coordinates: 372302..372559 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1612_RS01725	367382..368575	+	1194	WP_000675406.1	MFS transporter	-
F1612_RS01730	368799..369548	-	750	WP_000072463.1	hypothetical protein	-
F1612_RS01735	369743..371320	+	1578	WP_000143494.1	FMN-binding glutamate synthase family protein	-
F1612_RS01740	371488..371943	-	456	WP_000732091.1	DUF1307 domain-containing protein	-
F1612_RS01745	372302..372559	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F1612_RS01750	372559..372825	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
F1612_RS01755	373182..374258	+	1077	WP_045172647.1	M42 family metallopeptidase	-
F1612_RS01760	374506..375168	+	663	WP_006191024.1	ATP-binding cassette domain-containing protein	-
F1612_RS01765	375161..375937	+	777	WP_006191020.1	iron export ABC transporter permease subunit FetB	-
F1612_RS01770	376331..377518	+	1188	WP_000026187.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T139347 WP_000074043.1 NZ_CP043843:372559-372825 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T139347 NZ_CP058651:c4203317-4203144 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT139347 WP_000587618.1 NZ_CP043843:372302-372559 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT139347 NZ_CP058651:c4203641-4203345 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2