Detailed information of TA system TA139260

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1591372..1591743
• Replicon: chromosome
• Accession: NZ_CP043821
• Organism: Escherichia coli strain RM10740

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A839BBC2
• Locus tag: F1748_RS07905
• Protein ID: WP_021500490.1
• Coordinates: 1591549..1591743 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1591372..1591550 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1748_RS07880 (1587327)	1587327..1588700	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
F1748_RS07885 (1588829)	1588829..1589764	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
F1748_RS07890 (1589816)	1589816..1591051	-	1236	WP_072014550.1	site-specific integrase	-
F1748_RS07895 (1591053)	1591053..1591268	-	216	WP_000079604.1	excisionase XisR	-
- (1591372)	1591372..1591550	+	179	NuclAT_0	-	Antitoxin
- (1591372)	1591372..1591550	+	179	NuclAT_0	-	Antitoxin
- (1591372)	1591372..1591550	+	179	NuclAT_0	-	Antitoxin
- (1591372)	1591372..1591550	+	179	NuclAT_0	-	Antitoxin
F1748_RS07900 (1591368)	1591368..1591556	-	189	WP_032084364.1	DUF1187 family protein	-
F1748_RS07905 (1591549)	1591549..1591743	-	195	WP_021500490.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
F1748_RS07910 (1591807)	1591807..1592859	-	1053	WP_001004422.1	RecT family recombinase	-
F1748_RS07915 (1592871)	1592871..1595942	-	3072	WP_032084365.1	exodeoxyribonuclease VIII	-
F1748_RS07920 (1596044)	1596044..1596319	-	276	WP_001516463.1	phage protein	-
F1748_RS07925 (1596394)	1596394..1596564	-	171	WP_001516462.1	YdaE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1589816..1638968	49152

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7046.98 Da
• Isoelectric Point: 9.2886

>T139260 WP_021500490.1 NZ_CP043821:c1591743-1591549 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T139260 NZ_CP058596:4414342-4414683 [Escherichia coli]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT139260 NZ_CP043821:1591372-1591550 [Escherichia coli]
GACGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAATGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A839BBC2

Antitoxin