Detailed information of TA system TA139240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2703222..2703712
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FU792_RS12950
• Protein ID: WP_022925115.1
• Coordinates: 2703222..2703479 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: FU792_RS12955
• Protein ID: WP_028131032.1
• Coordinates: 2703485..2703712 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS12925	2698544..2698840	-	297	WP_075868511.1	hypothetical protein	-
FU792_RS12930	2698912..2699532	-	621	WP_022925119.1	response regulator transcription factor	-
FU792_RS12935	2699529..2700725	-	1197	WP_022925118.1	sensor histidine kinase	-
FU792_RS12940	2700876..2701967	+	1092	WP_028131033.1	ABC transporter permease	-
FU792_RS12945	2701964..2702678	+	715	Protein_2563	ABC transporter ATP-binding protein	-
FU792_RS12950	2703222..2703479	-	258	WP_022925115.1	Txe/YoeB family addiction module toxin	Toxin
FU792_RS12955	2703485..2703712	-	228	WP_028131032.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FU792_RS12960	2703956..2704807	-	852	WP_022925113.1	PRC and DUF2382 domain-containing protein	-
FU792_RS12965	2705660..2706382	-	723	WP_028131031.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
FU792_RS12970	2706449..2706721	-	273	WP_022925111.1	DUF4235 domain-containing protein	-
FU792_RS12975	2706890..2707180	+	291	WP_022925110.1	hypothetical protein	-
FU792_RS12980	2707155..2707598	+	444	WP_168714909.1	phage holin family protein	-
FU792_RS12985	2707579..2707908	+	330	WP_022925108.1	DUF3618 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2698057..2713481	15424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-64)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10315.76 Da
• Isoelectric Point: 7.5160

>T139240 WP_022925115.1 NZ_CP043808:c2703479-2703222 [Serinicoccus marinus DSM 15273]
VLLVWDEHAWEDYLWWQSQDHKVLKRINLLLKDIQRNGHAEIGKPEALKHDVADYWSRRITDEHRLIYKIAAHEIRIAAC
RYHYG

Nucleotide

• Length: 258 bp

>T139240 NZ_CP058576:4528-4686 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8330.33 Da
• Isoelectric Point: 4.3557

>AT139240 WP_028131032.1 NZ_CP043808:c2703712-2703485 [Serinicoccus marinus DSM 15273]
MSRYAEVLDGVTDREEVVVTRAGHEPVVIVSLADYESLRETAYLMRSPANARRLLDAMERLEAGGGQTHELIEAD

Nucleotide

• Length: 228 bp

>AT139240 NZ_CP058576:4417-4482 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC