Detailed information of TA system TA139238

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 2433271..2433841
• Replicon: chromosome
• Accession: NZ_CP043808
• Organism: Serinicoccus marinus DSM 15273

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FU792_RS11555
• Protein ID: WP_028131030.1
• Coordinates: 2433560..2433841 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FU792_RS11550
• Protein ID: WP_028131029.1
• Coordinates: 2433271..2433573 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU792_RS11520	2428636..2428928	-	293	Protein_2284	HigA family addiction module antidote protein	-
FU792_RS11525	2428888..2429195	-	308	Protein_2285	type II toxin-antitoxin system RelE/ParE family toxin	-
FU792_RS16795	2429337..2430038	-	702	WP_161600248.1	TIGR02391 family protein	-
FU792_RS16800	2430372..2431028	+	657	WP_022925098.1	hypothetical protein	-
FU792_RS11540	2431048..2432532	-	1485	WP_022925099.1	hypothetical protein	-
FU792_RS11545	2432644..2433207	-	564	WP_022925100.1	GNAT family N-acetyltransferase	-
FU792_RS11550	2433271..2433573	-	303	WP_028131029.1	HigA family addiction module antidote protein	Antitoxin
FU792_RS11555	2433560..2433841	-	282	WP_028131030.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FU792_RS11560	2434085..2434651	+	567	WP_141371700.1	hypothetical protein	-
FU792_RS11565	2434641..2435594	+	954	WP_022925103.1	hypothetical protein	-
FU792_RS11570	2435616..2435867	-	252	Protein_2294	hypothetical protein	-
FU792_RS11575	2435887..2437524	-	1638	WP_022926331.1	IS1634 family transposase	-
FU792_RS11580	2437627..2437941	-	315	Protein_2296	hypothetical protein	-
FU792_RS11585	2438166..2438474	-	309	WP_012397801.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2423482..2435852	12370

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (24-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 10.5605

>T139238 WP_028131030.1 NZ_CP043808:c2433841-2433560 [Serinicoccus marinus DSM 15273]
VIRSFGSKETERLWRRERVRSLDPRIHRVALRKLRQVGSAEVFDDLRVPPGSRLEPLKGDRVGQHSIRISDQWRICFVWT
AAGPEEVEIVDYH

Nucleotide

• Length: 282 bp

>T139238 NZ_CP058575:72270-72428 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10988.58 Da
• Isoelectric Point: 5.0618

>AT139238 WP_028131029.1 NZ_CP043808:c2433573-2433271 [Serinicoccus marinus DSM 15273]
MTTTDKIAPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGVTADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLVGDQIASITPLPIA

Nucleotide

• Length: 303 bp

>AT139238 NZ_CP058575:72159-72224 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC