Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2433271..2433841 Replicon chromosome
Accession NZ_CP043808
Organism Serinicoccus marinus DSM 15273

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FU792_RS11555 Protein ID WP_028131030.1
Coordinates 2433560..2433841 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FU792_RS11550 Protein ID WP_028131029.1
Coordinates 2433271..2433573 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU792_RS11520 2428636..2428928 - 293 Protein_2284 HigA family addiction module antidote protein -
FU792_RS11525 2428888..2429195 - 308 Protein_2285 type II toxin-antitoxin system RelE/ParE family toxin -
FU792_RS16795 2429337..2430038 - 702 WP_161600248.1 TIGR02391 family protein -
FU792_RS16800 2430372..2431028 + 657 WP_022925098.1 hypothetical protein -
FU792_RS11540 2431048..2432532 - 1485 WP_022925099.1 hypothetical protein -
FU792_RS11545 2432644..2433207 - 564 WP_022925100.1 GNAT family N-acetyltransferase -
FU792_RS11550 2433271..2433573 - 303 WP_028131029.1 HigA family addiction module antidote protein Antitoxin
FU792_RS11555 2433560..2433841 - 282 WP_028131030.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FU792_RS11560 2434085..2434651 + 567 WP_141371700.1 hypothetical protein -
FU792_RS11565 2434641..2435594 + 954 WP_022925103.1 hypothetical protein -
FU792_RS11570 2435616..2435867 - 252 Protein_2294 hypothetical protein -
FU792_RS11575 2435887..2437524 - 1638 WP_022926331.1 IS1634 family transposase -
FU792_RS11580 2437627..2437941 - 315 Protein_2296 hypothetical protein -
FU792_RS11585 2438166..2438474 - 309 WP_012397801.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2423482..2435852 12370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10917.47 Da        Isoelectric Point: 10.5605

>T139238 WP_028131030.1 NZ_CP043808:c2433841-2433560 [Serinicoccus marinus DSM 15273]
VIRSFGSKETERLWRRERVRSLDPRIHRVALRKLRQVGSAEVFDDLRVPPGSRLEPLKGDRVGQHSIRISDQWRICFVWT
AAGPEEVEIVDYH

Download         Length: 282 bp

>T139238 NZ_CP058575:72270-72428 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10988.58 Da        Isoelectric Point: 5.0618

>AT139238 WP_028131029.1 NZ_CP043808:c2433573-2433271 [Serinicoccus marinus DSM 15273]
MTTTDKIAPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGVTADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLVGDQIASITPLPIA

Download         Length: 303 bp

>AT139238 NZ_CP058575:72159-72224 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References