Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA-HipA |
| Location | 1582430..1583778 | Replicon | chromosome |
| Accession | NZ_CP043772 | ||
| Organism | Haemophilus influenzae biotype aegyptius strain HE24/F3037 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | E7A6T7 |
| Locus tag | F1539_RS08025 | Protein ID | WP_013526379.1 |
| Coordinates | 1582430..1583461 (-) | Length | 344 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | E7A6T6 |
| Locus tag | F1539_RS08030 | Protein ID | WP_013526378.1 |
| Coordinates | 1583458..1583778 (-) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F1539_RS08015 | 1578951..1580696 | + | 1746 | WP_013526381.1 | ABC transporter ATP-binding protein/permease | - |
| F1539_RS08020 | 1580689..1582347 | + | 1659 | WP_013526380.1 | ABC transporter ATP-binding protein/permease | - |
| F1539_RS08025 | 1582430..1583461 | - | 1032 | WP_013526379.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| F1539_RS08030 | 1583458..1583778 | - | 321 | WP_013526378.1 | type II toxin-antitoxin system HipA family toxin | Antitoxin |
| F1539_RS08035 | 1583766..1584074 | - | 309 | WP_005661200.1 | helix-turn-helix domain-containing protein | - |
| F1539_RS08040 | 1584275..1585276 | - | 1002 | WP_005690169.1 | class II fructose-bisphosphatase | - |
| F1539_RS08045 | 1585438..1585656 | + | 219 | WP_005650820.1 | cell division protein ZapB | - |
| F1539_RS08050 | 1585753..1586193 | + | 441 | WP_005667635.1 | FMN-binding protein MioC | - |
| F1539_RS08055 | 1586190..1586624 | + | 435 | WP_013526377.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
| F1539_RS10230 | 1586883..1587050 | + | 168 | WP_006995248.1 | hypothetical protein | - |
| F1539_RS08060 | 1587120..1587596 | - | 477 | WP_006995249.1 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | - |
| F1539_RS08065 | 1587593..1588270 | - | 678 | WP_006995250.1 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | - |
| F1539_RS08070 | 1588270..1588548 | - | 279 | WP_005661211.1 | cell division protein FtsB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 344 a.a. Molecular weight: 39685.29 Da Isoelectric Point: 6.7800
>T139229 WP_013526379.1 NZ_CP043772:c1583461-1582430 [Haemophilus influenzae biotype aegyptius]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPGEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREESNATLAKGFNTQYGEYIGDDFVEFGANIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPGEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREESNATLAKGFNTQYGEYIGDDFVEFGANIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL
Download Length: 1032 bp
>T139229 NZ_CP058574:2999052-2999546 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 12486.15 Da Isoelectric Point: 6.3254
>AT139229 WP_013526378.1 NZ_CP043772:c1583778-1583458 [Haemophilus influenzae biotype aegyptius]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ
Download Length: 321 bp
>AT139229 NZ_CP058574:2998762-2999055 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5C2QYK5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5C2R0D9 |