Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA-HipA |
| Location | 1403371..1404719 | Replicon | chromosome |
| Accession | NZ_CP043771 | ||
| Organism | Haemophilus influenzae biotype aegyptius strain HE15/F3028 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | E7A6T7 |
| Locus tag | F1538_RS07030 | Protein ID | WP_013526379.1 |
| Coordinates | 1403688..1404719 (+) | Length | 344 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | E7A6T6 |
| Locus tag | F1538_RS07025 | Protein ID | WP_013526378.1 |
| Coordinates | 1403371..1403691 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F1538_RS06985 | 1398601..1398879 | + | 279 | WP_005661211.1 | cell division protein FtsB | - |
| F1538_RS06990 | 1398879..1399556 | + | 678 | WP_006995250.1 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | - |
| F1538_RS06995 | 1399553..1400029 | + | 477 | WP_006995249.1 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | - |
| F1538_RS10200 | 1400099..1400266 | - | 168 | WP_006995248.1 | hypothetical protein | - |
| F1538_RS07000 | 1400525..1400959 | - | 435 | WP_013526377.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
| F1538_RS07005 | 1400956..1401396 | - | 441 | WP_005667635.1 | FMN-binding protein MioC | - |
| F1538_RS07010 | 1401493..1401711 | - | 219 | WP_005650820.1 | cell division protein ZapB | - |
| F1538_RS07015 | 1401873..1402874 | + | 1002 | WP_005690169.1 | class II fructose-bisphosphatase | - |
| F1538_RS07020 | 1403075..1403383 | + | 309 | WP_005661200.1 | helix-turn-helix domain-containing protein | - |
| F1538_RS07025 | 1403371..1403691 | + | 321 | WP_013526378.1 | type II toxin-antitoxin system HipA family toxin | Antitoxin |
| F1538_RS07030 | 1403688..1404719 | + | 1032 | WP_013526379.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| F1538_RS07035 | 1404802..1406460 | - | 1659 | WP_013526380.1 | ABC transporter ATP-binding protein/permease | - |
| F1538_RS07040 | 1406453..1408198 | - | 1746 | WP_013526381.1 | ABC transporter ATP-binding protein/permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 344 a.a. Molecular weight: 39685.29 Da Isoelectric Point: 6.7800
>T139223 WP_013526379.1 NZ_CP043771:1403688-1404719 [Haemophilus influenzae biotype aegyptius]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPGEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREESNATLAKGFNTQYGEYIGDDFVEFGANIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPGEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREESNATLAKGFNTQYGEYIGDDFVEFGANIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL
Download Length: 1032 bp
>T139223 NZ_CP058574:c1952435-1952061 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 107 a.a. Molecular weight: 12486.15 Da Isoelectric Point: 6.3254
>AT139223 WP_013526378.1 NZ_CP043771:1403371-1403691 [Haemophilus influenzae biotype aegyptius]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ
Download Length: 321 bp
>AT139223 NZ_CP058574:c1952892-1952524 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5C2QYK5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5C2R0D9 |