Detailed information of TA system TA139220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 372562..373205
• Replicon: chromosome
• Accession: NZ_CP043771
• Organism: Haemophilus influenzae biotype aegyptius strain HE15/F3028

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5C2R1D6
• Locus tag: F1538_RS01730
• Protein ID: WP_041174909.1
• Coordinates: 372867..373205 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: F1538_RS01725
• Protein ID: WP_006995911.1
• Coordinates: 372562..372870 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1538_RS01685	367787..368899	+	1113	WP_013525746.1	iron-sulfur cluster carrier protein ApbC	-
F1538_RS01690	369130..369393	+	264	WP_171034549.1	antitoxin MazE	-
F1538_RS01695	369393..369746	+	354	WP_006995906.1	type II toxin-antitoxin system PemK/MazF family toxin	-
F1538_RS01705	369859..370032	-	174	Protein_323	antitoxin	-
F1538_RS01710	370044..370706	-	663	WP_013525747.1	NAD(P)H-dependent oxidoreductase	-
F1538_RS01715	370820..371494	+	675	WP_013525748.1	N-acylneuraminate cytidylyltransferase	-
F1538_RS01720	371574..372149	+	576	Protein_326	DDE-type integrase/transposase/recombinase	-
F1538_RS01725	372562..372870	-	309	WP_006995911.1	helix-turn-helix domain-containing protein	Antitoxin
F1538_RS01730	372867..373205	-	339	WP_041174909.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F1538_RS01735	373838..376030	-	2193	WP_013525749.1	DUF927 domain-containing protein	-
F1538_RS01740	376018..376410	-	393	WP_006995914.1	hypothetical protein	-
F1538_RS01745	376403..377086	-	684	WP_013525750.1	hypothetical protein	-
F1538_RS01750	377073..377276	-	204	WP_006995916.1	hypothetical protein	-
F1538_RS01755	377266..377637	-	372	WP_013525751.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (11-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-80)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13150.10 Da
• Isoelectric Point: 9.2488

>T139220 WP_041174909.1 NZ_CP043771:c373205-372867 [Haemophilus influenzae biotype aegyptius]
VKLSFIELPPFERYRKAHLSDDEYRAFQNELLENLEKGDVIQNAGGLRKIRIADSERNKGKRGGARVIYYYLIRKSQILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ

Nucleotide

• Length: 339 bp

>T139220 NZ_CP058574:742008-742304 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11550.34 Da
• Isoelectric Point: 9.9619

>AT139220 WP_006995911.1 NZ_CP043771:c372870-372562 [Haemophilus influenzae biotype aegyptius]
MSKLFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Nucleotide

• Length: 309 bp

>AT139220 NZ_CP043771:c372870-372562 [Haemophilus influenzae biotype aegyptius]
ATGAGTAAATTATTTGATGAGCTTATAGAGGGGCTAAATGCCTATAAAGACTTTACACAGGGGAAAATAACGCTCAGAGT
AGAGACGCGTGAACGAATTGAACCTGCAAGCATTACAGCAGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCCGTTTTTGCGCAGAAGTTACGAACTAGTGTAAGAACCTATCAAGGTTGGGAGCAAGGGAAAACCAAACCTAGCGCA
CACGCCTCCTTATTGTTGCGCATGGTGGATAAAGCCCCGCAAACCTTTGAGCTCATCGCAGGGATATAA

Structures

Toxin

• AlphaFold DB: A0A5C2R1D6