139217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 1444170..1445518 Replicon chromosome
Accession NZ_CP043770
Organism Haemophilus influenzae biotype aegyptius strain HE7/F1946

Toxin (Protein)


Gene name HipT Uniprot ID E7A6T7
Locus tag F1537_RS07395 Protein ID WP_013526379.1
Coordinates 1444170..1445201 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID E7A6T6
Locus tag F1537_RS07400 Protein ID WP_013526378.1
Coordinates 1445198..1445518 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1537_RS07385 1440691..1442436 + 1746 WP_013526381.1 ABC transporter ATP-binding protein/permease -
F1537_RS07390 1442429..1444087 + 1659 WP_013526380.1 ABC transporter ATP-binding protein/permease -
F1537_RS07395 1444170..1445201 - 1032 WP_013526379.1 type II toxin-antitoxin system HipA family toxin Toxin
F1537_RS07400 1445198..1445518 - 321 WP_013526378.1 type II toxin-antitoxin system HipA family toxin Antitoxin
F1537_RS07405 1445506..1445814 - 309 WP_005661200.1 helix-turn-helix domain-containing protein -
F1537_RS07410 1446015..1447016 - 1002 WP_005690169.1 class II fructose-bisphosphatase -
F1537_RS07415 1447178..1447396 + 219 WP_005650820.1 cell division protein ZapB -
F1537_RS07420 1447493..1447933 + 441 WP_005667635.1 FMN-binding protein MioC -
F1537_RS07425 1447930..1448364 + 435 WP_013526377.1 D-tyrosyl-tRNA(Tyr) deacylase -
F1537_RS10230 1448623..1448790 + 168 WP_006995248.1 hypothetical protein -
F1537_RS07430 1448860..1449336 - 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
F1537_RS07435 1449333..1450010 - 678 WP_006995250.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
F1537_RS07440 1450010..1450288 - 279 WP_005661211.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39685.29 Da        Isoelectric Point: 6.7800

>T139217 WP_013526379.1 NZ_CP043770:c1445201-1444170 [Haemophilus influenzae biotype aegyptius]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPGEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREESNATLAKGFNTQYGEYIGDDFVEFGANIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T139217 NZ_CP058574:150192-150377 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12486.15 Da        Isoelectric Point: 6.3254

>AT139217 WP_013526378.1 NZ_CP043770:c1445518-1445198 [Haemophilus influenzae biotype aegyptius]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT139217 NZ_CP058574:150394-150804 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R0D9

References