Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 719844..720519 | Replicon | chromosome |
Accession | NZ_CP043766 | ||
Organism | Enterobacter hormaechei strain EB_P9_L5_03.19 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A837FDC1 |
Locus tag | F1597_RS03340 | Protein ID | WP_015571638.1 |
Coordinates | 719844..720143 (+) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A2J0PXC9 |
Locus tag | F1597_RS03345 | Protein ID | WP_015571639.1 |
Coordinates | 720154..720519 (+) | Length | 122 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F1597_RS03330 | 716221..718413 | + | 2193 | WP_017692801.1 | type I secretion system permease/ATPase | - |
F1597_RS03335 | 718433..719593 | + | 1161 | WP_085929677.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
F1597_RS03340 | 719844..720143 | + | 300 | WP_015571638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
F1597_RS03345 | 720154..720519 | + | 366 | WP_015571639.1 | HigA family addiction module antidote protein | Antitoxin |
F1597_RS03350 | 720546..721727 | - | 1182 | WP_017382758.1 | PLP-dependent aminotransferase family protein | - |
F1597_RS03355 | 721748..722635 | - | 888 | WP_033487545.1 | LysR family transcriptional regulator | - |
F1597_RS03360 | 722733..723335 | + | 603 | WP_033487546.1 | short chain dehydrogenase | - |
F1597_RS03365 | 723332..724063 | - | 732 | WP_017382760.1 | methyltransferase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11624.29 Da Isoelectric Point: 9.6776
>T139192 WP_015571638.1 NZ_CP043766:719844-720143 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK
Download Length: 300 bp
>T139192 NZ_CP058556:c4213420-4212998 [Streptomyces sp. CB04723]
GTGAGTGCGGCACTGTTCCTGATCGACACCAGTGCGCTCGCCCGCTTCCTCCGCGGCGGCGCCGAACAGTTCGGCTGGGA
CCAGGCCGCCTCAGCCGGACTCATCGCGACCTGCCCCGTCACCGAGCTGGAATTCTTCTACAGCGCGCGCTCCGCTGTGG
ACCGTGCGCGCGGCATCGAGGACCTGAAGTCGCTCTTCGGCTGGGTGCCCATCGACGATCGCGCGCACGATCGCGCCTGG
CAGGTTCAGGAGTTGCTGACCCAGCGTGGCCAACACCGCAGCGCCGGCGCAGTGGACCTCATCGTTGCCGCCACCGCAGA
GCTTCAAGGGCTGACCCTCCTGCACCGCGACCACGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCCATGCAGTGGT
ACGGCCCGGAGGCCGGCAAATGA
GTGAGTGCGGCACTGTTCCTGATCGACACCAGTGCGCTCGCCCGCTTCCTCCGCGGCGGCGCCGAACAGTTCGGCTGGGA
CCAGGCCGCCTCAGCCGGACTCATCGCGACCTGCCCCGTCACCGAGCTGGAATTCTTCTACAGCGCGCGCTCCGCTGTGG
ACCGTGCGCGCGGCATCGAGGACCTGAAGTCGCTCTTCGGCTGGGTGCCCATCGACGATCGCGCGCACGATCGCGCCTGG
CAGGTTCAGGAGTTGCTGACCCAGCGTGGCCAACACCGCAGCGCCGGCGCAGTGGACCTCATCGTTGCCGCCACCGCAGA
GCTTCAAGGGCTGACCCTCCTGCACCGCGACCACGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCCATGCAGTGGT
ACGGCCCGGAGGCCGGCAAATGA
Antitoxin
Download Length: 122 a.a. Molecular weight: 13705.73 Da Isoelectric Point: 9.5936
>AT139192 WP_015571639.1 NZ_CP043766:720154-720519 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA
Download Length: 366 bp
>AT139192 NZ_CP058556:c4213632-4213417 [Streptomyces sp. CB04723]
ATGAGTCGCACAGTGATCGACCTCGATGACGAACTGCTGGCCGACGTGGCTCAAGCGCTGGGGACCGGCACCAAAAAGGA
GACGGTCAACACCGCACTGCGTGAGGTGCTCGAGAACCGCCGGCGGGCCCTCGCTCTCACTCGGCTACGGAAGGCGGCAA
GCGAGGGAAGCTTCGACCTGGAGCTCTTCGAGGAAAAAAGGAACTACCGGCGGTGA
ATGAGTCGCACAGTGATCGACCTCGATGACGAACTGCTGGCCGACGTGGCTCAAGCGCTGGGGACCGGCACCAAAAAGGA
GACGGTCAACACCGCACTGCGTGAGGTGCTCGAGAACCGCCGGCGGGCCCTCGCTCTCACTCGGCTACGGAAGGCGGCAA
GCGAGGGAAGCTTCGACCTGGAGCTCTTCGAGGAAAAAAGGAACTACCGGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A837FDC1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J0PXC9 |