Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 719844..720519 Replicon chromosome
Accession NZ_CP043766
Organism Enterobacter hormaechei strain EB_P9_L5_03.19

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag F1597_RS03340 Protein ID WP_015571638.1
Coordinates 719844..720143 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag F1597_RS03345 Protein ID WP_015571639.1
Coordinates 720154..720519 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1597_RS03330 716221..718413 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
F1597_RS03335 718433..719593 + 1161 WP_085929677.1 HlyD family efflux transporter periplasmic adaptor subunit -
F1597_RS03340 719844..720143 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1597_RS03345 720154..720519 + 366 WP_015571639.1 HigA family addiction module antidote protein Antitoxin
F1597_RS03350 720546..721727 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
F1597_RS03355 721748..722635 - 888 WP_033487545.1 LysR family transcriptional regulator -
F1597_RS03360 722733..723335 + 603 WP_033487546.1 short chain dehydrogenase -
F1597_RS03365 723332..724063 - 732 WP_017382760.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T139192 WP_015571638.1 NZ_CP043766:719844-720143 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T139192 NZ_CP058556:c4213420-4212998 [Streptomyces sp. CB04723]
GTGAGTGCGGCACTGTTCCTGATCGACACCAGTGCGCTCGCCCGCTTCCTCCGCGGCGGCGCCGAACAGTTCGGCTGGGA
CCAGGCCGCCTCAGCCGGACTCATCGCGACCTGCCCCGTCACCGAGCTGGAATTCTTCTACAGCGCGCGCTCCGCTGTGG
ACCGTGCGCGCGGCATCGAGGACCTGAAGTCGCTCTTCGGCTGGGTGCCCATCGACGATCGCGCGCACGATCGCGCCTGG
CAGGTTCAGGAGTTGCTGACCCAGCGTGGCCAACACCGCAGCGCCGGCGCAGTGGACCTCATCGTTGCCGCCACCGCAGA
GCTTCAAGGGCTGACCCTCCTGCACCGCGACCACGACTTCGAGTGCATCGCCGCCGTCACCGGCCAGGCCATGCAGTGGT
ACGGCCCGGAGGCCGGCAAATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT139192 WP_015571639.1 NZ_CP043766:720154-720519 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp

>AT139192 NZ_CP058556:c4213632-4213417 [Streptomyces sp. CB04723]
ATGAGTCGCACAGTGATCGACCTCGATGACGAACTGCTGGCCGACGTGGCTCAAGCGCTGGGGACCGGCACCAAAAAGGA
GACGGTCAACACCGCACTGCGTGAGGTGCTCGAGAACCGCCGGCGGGCCCTCGCTCTCACTCGGCTACGGAAGGCGGCAA
GCGAGGGAAGCTTCGACCTGGAGCTCTTCGAGGAAAAAAGGAACTACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References