Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4726204..4726754 Replicon chromosome
Accession NZ_CP043627
Organism Methylobacterium aquaticum strain BG2

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F1D61_RS21570 Protein ID WP_203154063.1
Coordinates 4726482..4726754 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag F1D61_RS21565 Protein ID WP_203159196.1
Coordinates 4726204..4726485 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1D61_RS21540 4721455..4721793 + 339 WP_203154043.1 hypothetical protein -
F1D61_RS21545 4721950..4722378 + 429 WP_203154045.1 hypothetical protein -
F1D61_RS21550 4722512..4723477 - 966 WP_203154053.1 extensin family protein -
F1D61_RS21555 4723592..4724451 - 860 Protein_4225 DMT family transporter -
F1D61_RS21560 4724694..4726055 + 1362 WP_203159195.1 PLP-dependent aminotransferase family protein -
F1D61_RS21565 4726204..4726485 + 282 WP_203159196.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F1D61_RS21570 4726482..4726754 + 273 WP_203154063.1 Txe/YoeB family addiction module toxin Toxin
F1D61_RS21580 4726966..4728210 - 1245 WP_203159197.1 HlyD family secretion protein -
F1D61_RS21585 4728274..4728468 - 195 WP_203154065.1 DUF1656 domain-containing protein -
F1D61_RS21590 4728472..4730490 - 2019 WP_203154067.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10411.77 Da        Isoelectric Point: 8.9546

>T139166 WP_203154063.1 NZ_CP043627:4726482-4726754 [Methylobacterium aquaticum]
MKLAVSDDAWNEYLSWKGESSATLQRINDLIKEIKRTPFTGTGKPEPLKFKLEGWWSRRISGEHRLVYRVSGSGAAQTLE
IAQCRWHYDD

Download         Length: 273 bp

>T139166 NZ_CP058544:c3278264-3276942 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACACTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10585.77 Da        Isoelectric Point: 4.6017

>AT139166 WP_203159196.1 NZ_CP043627:4726204-4726485 [Methylobacterium aquaticum]
VTHVSLTDFRQSIATHFDRVERDREELVVTRQGHEPLVLLPLAELNSLRETLHLLGSPANARRLMRSIEQLDADQGIERS
LIEDDRSDEATEG

Download         Length: 282 bp

>AT139166 NZ_CP043627:4726204-4726485 [Methylobacterium aquaticum]
GTGACGCATGTGAGCCTGACTGATTTCCGACAGAGCATCGCGACCCACTTCGACCGGGTCGAACGCGACCGGGAAGAGCT
GGTGGTCACCCGTCAGGGTCACGAGCCCCTGGTGCTGCTCCCCCTCGCCGAGCTGAACAGCCTGCGGGAAACCCTGCACC
TCCTCGGCTCGCCTGCCAATGCGCGGCGCCTGATGCGGTCCATCGAACAGCTCGACGCTGACCAAGGGATCGAACGCTCT
CTGATCGAGGACGACCGGTCCGACGAGGCGACCGAGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References