Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6214869..6215459 Replicon chromosome
Accession NZ_CP043626
Organism Pseudomonas denitrificans (nom. rej.) strain BG1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag F1C79_RS28985 Protein ID WP_151189324.1
Coordinates 6215181..6215459 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F1C79_RS28980 Protein ID WP_138212037.1
Coordinates 6214869..6215168 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1C79_RS28960 6210086..6211063 + 978 WP_081517182.1 nitronate monooxygenase family protein -
F1C79_RS28965 6211128..6212378 + 1251 WP_081517183.1 OprD family porin -
F1C79_RS28970 6212513..6213196 + 684 WP_151189322.1 TetR family transcriptional regulator -
F1C79_RS28975 6213193..6214842 + 1650 WP_151189323.1 acyl-CoA dehydrogenase family protein -
F1C79_RS28980 6214869..6215168 - 300 WP_138212037.1 HigA family addiction module antidote protein Antitoxin
F1C79_RS28985 6215181..6215459 - 279 WP_151189324.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1C79_RS28990 6215630..6216103 - 474 WP_167523256.1 Bro-N domain-containing protein -
F1C79_RS28995 6216652..6218127 + 1476 WP_138212040.1 AMP nucleosidase -
F1C79_RS29000 6218309..6219085 + 777 WP_151189326.1 deoxyribose-phosphate aldolase -
F1C79_RS29005 6219202..6219765 + 564 WP_151189327.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10483.94 Da        Isoelectric Point: 8.2916

>T139162 WP_151189324.1 NZ_CP043626:c6215459-6215181 [Pseudomonas denitrificans (nom. rej.)]
MITSFACKHTQALFEGTCPKAFRAFQAQAERKLQMLDAAATLDFLRSPPGNRLEGLQGNRAGQYSIRINGQWRICFRWVD
GNVHDVEIVDYH

Download         Length: 279 bp

>T139162 NZ_CP058544:c1394914-1394537 [Klebsiella pneumoniae]
ATGAAAATATTATCAGACTCCCCCACACGGGCGGCGCCGTCGCGCCCGTCTCCCGTTGAAATCTGGCAGACTCTGTTGAC
GTACCTGCTGGATCAGCACTACGGTCTTACGCTTAACGACACACCGTTTGGCCACGATGGCATGATCCAGGAGCATATTG
ACACCGGGATCACCCTGTGTGATGCGGTGAATCTTATCGTCGAAAAATACAAACTGGTCCGTATCGATCGTCACGGTTTC
AGCGCAGACACACAGTCACCGCTTATCGGCAGTATCGATATCCTGCGGGCCCGAAAAGAAACTGGGCTGATGACCCGCCA
TGGCTACAGAGCGATTACTGATATCACGACGGGTAAATACAGTGAGGCCGGGCAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11141.70 Da        Isoelectric Point: 6.4692

>AT139162 WP_138212037.1 NZ_CP043626:c6215168-6214869 [Pseudomonas denitrificans (nom. rej.)]
MTQNRMRPVHPGEILREEYLAPLEMSANALATALRVPATRIHEIVNERRSITADTALRLARYFGGDAQSWVNLQTAFDLR
VAELESGQQIIDEIKPRAA

Download         Length: 300 bp

>AT139162 NZ_CP058544:c1395314-1394955 [Klebsiella pneumoniae]
TTGTCGAAGAAAACCACGATAACAACGCATGATATCAGCGAACCCTGGTGGGGGCTCAGGCGCAGTGTCTCTCCGTGTTT
TGGGGCCCGTCTGGTCCAGGAGGGGAATCGGCTGCATTATCTGGCTGACCGTGCGAACTTTGATGGTCAGTTCTGCGATG
CGGATTTGCGCCATCTTGACCAGGCTTTCCCGGTATTGATGAAACAGCTGGAGTTAATGCTTACCAGCGGTGAACTGAAT
CCTCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGTCTGACCTGCGAGGCCGATACCCTCGGCTCACACGGTTACCT
TTACCTCGCGATTTACACAACGCCTGCTACTGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References