Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 648953..649647 Replicon chromosome
Accession NZ_CP043571
Organism Pseudomonas migulae strain R1-9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag F0Q00_RS02875 Protein ID WP_182343206.1
Coordinates 648953..649249 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F0Q00_RS02880 Protein ID WP_103397313.1
Coordinates 649246..649647 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0Q00_RS02840 644632..645177 - 546 WP_182343200.1 hypothetical protein -
F0Q00_RS02845 645174..645428 - 255 WP_182343202.1 acyl carrier protein -
F0Q00_RS02850 645438..645698 - 261 WP_166592761.1 acyl carrier protein -
F0Q00_RS02855 645679..646488 - 810 WP_166592760.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
F0Q00_RS02860 646464..647183 - 720 WP_182343204.1 beta-ketoacyl synthase chain length factor -
F0Q00_RS02865 647539..648309 + 771 WP_166592758.1 ParA family protein -
F0Q00_RS02870 648324..648758 - 435 WP_166592757.1 thioredoxin TrxC -
F0Q00_RS02875 648953..649249 + 297 WP_182343206.1 type II toxin-antitoxin system HigB family toxin Toxin
F0Q00_RS02880 649246..649647 + 402 WP_103397313.1 transcriptional regulator Antitoxin
F0Q00_RS02885 649654..651117 - 1464 WP_182343208.1 YdiU family protein -
F0Q00_RS02890 651166..654516 - 3351 WP_182343210.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(19-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11482.36 Da        Isoelectric Point: 10.5487

>T139037 WP_182343206.1 NZ_CP043571:648953-649249 [Pseudomonas migulae]
MHVLTEKRVREAKVRWPMAANALDHWYQLAKGSKPSDFAAMRATFPAVDKVGELHVFDIGGNKLRLIAFVRYRSQKLYIK
PVLDHREYDRGKWKEEKA

Download         Length: 297 bp

>T139037 NZ_CP058342:1078660-1078995 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 15178.37 Da        Isoelectric Point: 4.8298

>AT139037 WP_103397313.1 NZ_CP043571:649246-649647 [Pseudomonas migulae]
MSVLIKKAAEHWEFVSPLLRKPKSEDDYDLLAHALDELLEMTGDDESHPLMSLVDIIGDWIEEWDHKHHPMPKPSGVEIL
GYLMREHGLSQSDLPGVGPQSVVSEILSGKRQLNLRQVRWLAERFSVSVEVFI

Download         Length: 402 bp

>AT139037 NZ_CP058342:1078412-1078660 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References