Detailed information of TA system TA138952

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 2491197..2491609
• Replicon: chromosome
• Accession: NZ_CP043539
• Organism: Escherichia coli O157 strain Al Ain

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: F0L19_RS12735
• Protein ID: WP_000132630.1
• Coordinates: 2491268..2491609 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	2491197..2491273 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0L19_RS12725	2487824..2489293	+	1470	WP_001302468.1	type I restriction-modification system subunit M	-
F0L19_RS12730	2489293..2491047	+	1755	WP_000110082.1	restriction endonuclease subunit S	-
-	2491197..2491273	-	77	NuclAT_14	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_14	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_14	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_14	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_15	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_15	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_15	-	Antitoxin
-	2491197..2491273	-	77	NuclAT_15	-	Antitoxin
F0L19_RS12735	2491268..2491609	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
F0L19_RS12740	2491656..2492819	-	1164	WP_001304006.1	DUF1524 domain-containing protein	-
F0L19_RS12745	2492867..2493748	-	882	WP_001304007.1	DUF262 domain-containing protein	-
F0L19_RS12750	2493845..2494009	-	165	WP_000394274.1	DUF1127 domain-containing protein	-
F0L19_RS12755	2494186..2495598	+	1413	WP_000199295.1	PLP-dependent aminotransferase family protein	-
F0L19_RS27775	2495841..2496041	-	201	WP_001310455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T138952 WP_000132630.1 NZ_CP043539:2491268-2491609 [Escherichia coli O157]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T138952 NZ_CP043539:2491268-2491609 [Escherichia coli O157]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT138952 NZ_CP043539:c2491273-2491197 [Escherichia coli O157]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin