Detailed information of TA system TA138943

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1181125..1181350
• Replicon: chromosome
• Accession: NZ_CP043539
• Organism: Escherichia coli O157 strain Al Ain

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: F0L19_RS06415
• Protein ID: WP_000813263.1
• Coordinates: 1181125..1181280 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1181292..1181350 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0L19_RS06380	1176579..1177292	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
F0L19_RS06385	1177430..1177626	-	197	Protein_1213	TrmB family transcriptional regulator	-
F0L19_RS06390	1177913..1178731	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
F0L19_RS06395	1178883..1179254	-	372	WP_000090264.1	antitermination protein	-
F0L19_RS06400	1179244..1179615	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
F0L19_RS06405	1179628..1180677	-	1050	WP_001265172.1	DUF968 domain-containing protein	-
F0L19_RS06410	1180679..1180957	-	279	WP_001341388.1	hypothetical protein	-
F0L19_RS06415	1181125..1181280	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1181292..1181350	+	59	-	-	Antitoxin
F0L19_RS06435	1181885..1182658	+	774	WP_000160654.1	alpha/beta hydrolase	-
F0L19_RS06440	1183010..1183423	-	414	WP_001151233.1	DUF977 family protein	-
F0L19_RS06445	1183439..1184209	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
F0L19_RS06450	1184231..1184977	-	747	WP_000788751.1	ATP-binding protein	-
F0L19_RS06455	1184984..1186075	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T138943 WP_000813263.1 NZ_CP043539:c1181280-1181125 [Escherichia coli O157]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T138943 NZ_CP058307:838010-838369 [Avibacterium paragallinarum]
ATGGTGGTAAAGAAAAAATGGGAAGTCATTGCAACAGCGAGATTTAAAATATGGTTAAAAGAGCAAGATGAGGCTACAAG
GATTTCTGTTTTTAATGCATTAAATAATTTGCGGTTCTATGGTCCTCAATTATCTCGTCCCTATGTAGATACCATAAAAG
GTTCTCAATATCCCAATATGAAAGAGTTGCGTATTCAACATAAAAGCAAGCCACTACGAGCATTTTTTGCATTCGATCCG
CTCAGGCAAGCAATTGTTCTATGTGCTGGAAATAAAAGTAATAATAAACAATTTTACAAACAAATGATTACGATTGCAGA
TGCAGAATTTACCGATTATTTAGCCACATTGGAGAAATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT138943 NZ_CP043539:1181292-1181350 [Escherichia coli O157]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin