Detailed information of TA system TA138941

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 693117..693342
• Replicon: chromosome
• Accession: NZ_CP043539
• Organism: Escherichia coli O157 strain Al Ain

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: F0L19_RS03495
• Protein ID: WP_000935259.1
• Coordinates: 693117..693329 (-)
• Length: 71 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	693284..693342 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F0L19_RS03445	688120..688551	-	432	WP_001302123.1	tellurite resistance protein	-
F0L19_RS03460	689002..689715	-	714	WP_000301797.1	helix-turn-helix domain-containing protein	-
F0L19_RS03465	689851..690048	-	198	WP_000917763.1	hypothetical protein	-
F0L19_RS03470	690273..690827	-	555	WP_000640035.1	DUF1133 family protein	-
F0L19_RS03475	690890..691195	-	306	WP_001217444.1	RusA family crossover junction endodeoxyribonuclease	-
F0L19_RS03480	691208..692257	-	1050	WP_001265229.1	DUF968 domain-containing protein	-
F0L19_RS03485	692259..692531	-	273	WP_000191872.1	hypothetical protein	-
F0L19_RS03490	692653..692997	-	345	WP_000756596.1	YgiW/YdeI family stress tolerance OB fold protein	-
F0L19_RS03495	693117..693329	-	213	WP_000935259.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	693284..693342	+	59	-	-	Antitoxin
F0L19_RS03505	693557..694114	-	558	WP_000104474.1	DUF551 domain-containing protein	-
F0L19_RS03510	694116..694334	-	219	WP_000683609.1	DUF4014 family protein	-
F0L19_RS03515	694462..694773	-	312	WP_001289673.1	hypothetical protein	-
F0L19_RS03520	694766..694993	-	228	WP_000699809.1	hypothetical protein	-
F0L19_RS03525	694990..695271	-	282	WP_000603384.1	DNA-binding protein	-
F0L19_RS03530	695304..696020	-	717	WP_000450627.1	DUF1627 domain-containing protein	-
F0L19_RS03535	696054..696515	-	462	WP_000139447.1	replication protein	-
F0L19_RS03540	696508..697551	-	1044	WP_001262402.1	hypothetical protein	-
F0L19_RS03545	697620..698045	-	426	WP_000693878.1	Rha family transcriptional regulator	-
F0L19_RS03550	698029..698271	-	243	WP_000747948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7' / paa	656109..752144	96035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7887.47 Da
• Isoelectric Point: 9.2654

>T138941 WP_000935259.1 NZ_CP043539:c693329-693117 [Escherichia coli O157]
MLNTCRLASYVPKGKEKQAMKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Nucleotide

• Length: 213 bp

>T138941 NZ_CP058307:287030-287395 [Avibacterium paragallinarum]
ATGAAACAAGAATGGGAAGTTATTTTACAAGACCCACTTTTAAATTGGCTTGAAACATTAGCAGAAGATGACTTATTAAA
AGTCTATGCGGCATTAGCGTTATTATCAACAGAAGGACCGCAATTAGGCAGACCTTATGCCGATACTATTCAAGGTTCTA
AATATACCAATTTAAAAGAATTGAGAGTACAGTCTAAATTATCCGTTTTCCGTTTGTTTTATATATTTGATCCCATTCGA
CAGGCTATTGTGCTATGTGGGGGAGATAAAAAAGGCAAAAAAGAAAAGCTCTTTTACAAAGAGATGATCACACTTGCCGA
ACAAACTTATGATAATTACCTTTCTGAATTTTTAAAGGAGCAATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT138941 NZ_CP043539:693284-693342 [Escherichia coli O157]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Antitoxin