Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4745331..4745975 Replicon chromosome
Accession NZ_CP043538
Organism Methylobacterium mesophilicum SR1.6/6

Toxin (Protein)


Gene name higB Uniprot ID A0A6B9FRN0
Locus tag MMSR116_RS22535 Protein ID WP_039894350.1
Coordinates 4745331..4745615 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MMSR116_RS22540 Protein ID WP_010686242.1
Coordinates 4745652..4745975 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMSR116_RS22525 4743143..4743916 - 774 WP_010686244.1 ferredoxin--NADP reductase -
MMSR116_RS22530 4744246..4745196 - 951 WP_010686243.1 ring-cleaving dioxygenase -
MMSR116_RS22535 4745331..4745615 + 285 WP_039894350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMSR116_RS22540 4745652..4745975 + 324 WP_010686242.1 HigA family addiction module antidote protein Antitoxin
MMSR116_RS22545 4746005..4747300 - 1296 WP_010686241.1 insulinase family protein -
MMSR116_RS22550 4747404..4748813 - 1410 WP_010686240.1 insulinase family protein -
MMSR116_RS22555 4748975..4749634 - 660 WP_010686239.1 hypothetical protein -
MMSR116_RS22560 4749795..4750310 - 516 WP_010686238.1 signal peptidase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(17-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-86)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10724.40 Da        Isoelectric Point: 10.7939

>T138928 WP_039894350.1 NZ_CP043538:4745331-4745615 [Methylobacterium mesophilicum SR1.6/6]
MPIRSVANAMTEAVFQGRHPRSIPAAILNVARRKLRQVHAAASLQDLKVPPGNKLHPLTKDCNRQHAVWINDQFRICFRW
TETGPEAVEIVDYR

Download         Length: 285 bp

>T138928 NZ_CP058302:c4388385-4388278 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11779.51 Da        Isoelectric Point: 5.7189

>AT138928 WP_010686242.1 NZ_CP043538:4745652-4745975 [Methylobacterium mesophilicum SR1.6/6]
MAIAYEADTTLPPLHPGEVLREDFLIPLGLSAGAIARACHVPRTRIERIAAEQIGISTDTALRLGRYLGTRADFWLNLQR
QFELETRSRTLGPEIERIAPLASAEAA

Download         Length: 324 bp

>AT138928 NZ_CP058302:4388433-4388499 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B9FRN0

Antitoxin

Source ID Structure

References