Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4689693..4690339 Replicon chromosome
Accession NZ_CP043511
Organism Enterobacter kobei strain EB_P8_L5_01.19

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FZO55_RS22950 Protein ID WP_058690226.1
Coordinates 4689693..4690043 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FZO55_RS22955 Protein ID WP_032635284.1
Coordinates 4690040..4690339 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZO55_RS22925 4685454..4686575 + 1122 Protein_4404 IS3 family transposase -
FZO55_RS22930 4686780..4688285 - 1506 WP_058690223.1 DNA polymerase -
FZO55_RS22935 4688531..4688692 - 162 WP_072205328.1 DUF3950 domain-containing protein -
FZO55_RS22940 4688821..4689162 + 342 WP_058690222.1 SymE family type I addiction module toxin -
FZO55_RS22950 4689693..4690043 + 351 WP_058690226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FZO55_RS22955 4690040..4690339 + 300 WP_032635284.1 XRE family transcriptional regulator Antitoxin
FZO55_RS22960 4690369..4690806 - 438 WP_058690221.1 acetyltransferase -
FZO55_RS22965 4690909..4691907 - 999 WP_058690220.1 class I SAM-dependent methyltransferase -
FZO55_RS22970 4691986..4692510 - 525 WP_014881956.1 lipocalin family protein -
FZO55_RS22975 4692628..4693353 + 726 WP_014881955.1 MerR family transcriptional regulator -
FZO55_RS22980 4693453..4693863 + 411 WP_014881954.1 hydroxyisourate hydrolase -
FZO55_RS22985 4693966..4694925 + 960 WP_023336511.1 DUF523 and DUF1722 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13481.52 Da        Isoelectric Point: 6.9819

>T138922 WP_058690226.1 NZ_CP043511:4689693-4690043 [Enterobacter kobei]
MWTVLFGKVFELWLLEQEEGLQEKVLADMLNLQNFGPRLPRPYADTVKGSQYNNMKELRIQYAGRPIRALFAFDPERQAI
VLCAGNKSNDKAFYEKLIRIADDEFTRHLTSLETAK

Download         Length: 351 bp

>T138922 NZ_CP058302:2942605-2942946 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGAC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCAGTCGATATTTTGCGGGCGCGGCAGGCTACAGGTCTGCTGCGTCGCAG
CCATAACACCACGGCACGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11160.04 Da        Isoelectric Point: 6.9842

>AT138922 WP_032635284.1 NZ_CP043511:4690040-4690339 [Enterobacter kobei]
VKTLNELIASRSPESQQRIKEMAEEMILETGLQLLREELRLSQKNVAELMGVSQPAVTQIEQRGNELKIATLKRYIEAMG
GKLCIDVELPTGKRVAFHI

Download         Length: 300 bp

>AT138922 NZ_CP058302:2942239-2942574 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCGCCTGCCAAAAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References