Detailed information of TA system TA138907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 40915..41517
• Replicon: chromosome
• Accession: NZ_CP043511
• Organism: Enterobacter kobei strain EB_P8_L5_01.19

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FZO55_RS00195
• Protein ID: WP_058690340.1
• Coordinates: 40915..41226 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B2XUJ3
• Locus tag: FZO55_RS00200
• Protein ID: WP_032635182.1
• Coordinates: 41227..41517 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZO55_RS00165	35944..36744	+	801	WP_047343714.1	DeoR/GlpR family DNA-binding transcription regulator	-
FZO55_RS00170	36864..37463	+	600	WP_023331629.1	glucose-1-phosphatase	-
FZO55_RS00175	37457..38337	+	881	Protein_28	virulence factor BrkB family protein	-
FZO55_RS00180	38334..38771	+	438	WP_014885747.1	D-tyrosyl-tRNA(Tyr) deacylase	-
FZO55_RS00185	38816..39757	+	942	WP_023336483.1	fatty acid biosynthesis protein FabY	-
FZO55_RS00190	39766..40686	-	921	WP_058690339.1	alpha/beta hydrolase	-
FZO55_RS00195	40915..41226	+	312	WP_058690340.1	hypothetical protein	Toxin
FZO55_RS00200	41227..41517	+	291	WP_032635182.1	helix-turn-helix domain-containing protein	Antitoxin
FZO55_RS00205	41559..42488	-	930	WP_014885738.1	formate dehydrogenase accessory protein FdhE	-
FZO55_RS00210	42485..43120	-	636	WP_008501832.1	formate dehydrogenase cytochrome b556 subunit	-
FZO55_RS00215	43117..44019	-	903	WP_014833793.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12264.32 Da
• Isoelectric Point: 10.1230

>T138907 WP_058690340.1 NZ_CP043511:40915-41226 [Enterobacter kobei]
MLFIETDIFTEDVKTLLDDDEYHKLQVFLVTQPNYGDLIQNTGGLRKIRWFSGSKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSAKEKAILKKMIERW

Nucleotide

• Length: 312 bp

>T138907 NZ_CP058281:1593729-1594010 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCCGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGCCTCAAAGAGCAAAAACCACTCCAACAAAAGTATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10703.22 Da
• Isoelectric Point: 10.5888

>AT138907 WP_032635182.1 NZ_CP043511:41227-41517 [Enterobacter kobei]
MDKALFERLTQSIAQMNEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Nucleotide

• Length: 291 bp

>AT138907 NZ_CP058281:1593422-1593736 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACGCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TGCGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCGTAATGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B2XUJ3