Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3372463..3373262 Replicon chromosome
Accession NZ_CP043487
Organism Escherichia coli strain AQ15

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag FQT78_RS16225 Protein ID WP_000347267.1
Coordinates 3372798..3373262 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag FQT78_RS16220 Protein ID WP_001307405.1
Coordinates 3372463..3372798 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT78_RS16205 3368248..3369018 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
FQT78_RS16210 3369034..3370368 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
FQT78_RS16215 3370743..3372314 + 1572 WP_001273741.1 galactarate dehydratase -
FQT78_RS16220 3372463..3372798 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
FQT78_RS16225 3372798..3373262 + 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
FQT78_RS16230 3373317..3374126 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
FQT78_RS16235 3374375..3375655 + 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
FQT78_RS16240 3375678..3376151 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
FQT78_RS16245 3376162..3376941 + 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
FQT78_RS16250 3376931..3377809 + 879 WP_001298758.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
FQT78_RS16255 3377827..3378261 + 435 WP_000948824.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3363315..3373262 9947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T138881 WP_000347267.1 NZ_CP043487:3372798-3373262 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T138881 NZ_CP058242:2678246-2678425 [Bacillus subtilis]
ATGTCGACCTATGAATCTCTAATGGTCATGATCGGCTTTGCCAATTTAATAGGCGGGATTATGACATGGGTAATATCTCT
TTTAACATTATTATTCATGCTTAGAAAAAAAGACACTCATCCTATTTACATTACTGTAAAGGAAAAGTGTCTACACGAGG
ACCCTCCTATTAAAGGGTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT138881 WP_001307405.1 NZ_CP043487:3372463-3372798 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT138881 NZ_CP043487:3372463-3372798 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACACGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References