Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2167474..2167976 Replicon chromosome
Accession NZ_CP043487
Organism Escherichia coli strain AQ15

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FQT78_RS10560 Protein ID WP_000767829.1
Coordinates 2167474..2167728 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FQT78_RS10565 Protein ID WP_001259255.1
Coordinates 2167725..2167976 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQT78_RS10530 2162489..2162716 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
FQT78_RS10535 2162730..2163788 - 1059 WP_000492346.1 transport protein YeeE -
FQT78_RS10540 2163967..2165325 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FQT78_RS10545 2165315..2165377 - 63 WP_010723108.1 membrane protein YoeI -
FQT78_RS10550 2165592..2166521 - 930 WP_000803351.1 LysR family transcriptional regulator -
FQT78_RS10555 2166567..2167391 - 825 WP_000754749.1 SDR family oxidoreductase -
FQT78_RS10560 2167474..2167728 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FQT78_RS10565 2167725..2167976 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FQT78_RS10570 2168259..2168309 + 51 WP_001364200.1 his operon leader peptide -
FQT78_RS10575 2168455..2169354 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
FQT78_RS10580 2169360..2170664 + 1305 WP_001349967.1 histidinol dehydrogenase -
FQT78_RS10585 2170661..2171731 + 1071 WP_000108957.1 histidinol-phosphate transaminase -
FQT78_RS10590 2171731..2172798 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T138877 WP_000767829.1 NZ_CP043487:c2167728-2167474 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T138877 NZ_CP058242:c2219769-2219518 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACCCATATCACATTCATTGGCTTATTCTTAATGTTTCAACTCATCAAAGATTACTTCAGCAGCGAAGGACAGGCGCTAA
TCAACACAATTTTTGTTGTCACATGTATCATTGCCATATTGTTATGGATCATCTATTGTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT138877 WP_001259255.1 NZ_CP043487:c2167976-2167725 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT138877 NZ_CP058242:2219747-2219847 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References