Detailed information of TA system TA138862

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1451249..1451620
• Replicon: chromosome
• Accession: NZ_CP043487
• Organism: Escherichia coli strain AQ15

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: FQT78_RS06915
• Protein ID: WP_001317028.1
• Coordinates: 1451426..1451620 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1451249..1451427 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQT78_RS06890	1447204..1448577	+	1374	WP_000123740.1	ATP-dependent RNA helicase DbpA	-
FQT78_RS06895	1448706..1449641	-	936	WP_001157422.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
FQT78_RS06900	1449693..1450928	-	1236	WP_000040852.1	site-specific integrase	-
FQT78_RS06905	1450930..1451145	-	216	WP_000079604.1	excisionase XisR	-
FQT78_RS06910	1451224..1451433	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
-	1451249..1451427	+	179	NuclAT_0	-	Antitoxin
-	1451249..1451427	+	179	NuclAT_0	-	Antitoxin
-	1451249..1451427	+	179	NuclAT_0	-	Antitoxin
-	1451249..1451427	+	179	NuclAT_0	-	Antitoxin
FQT78_RS06915	1451426..1451620	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
FQT78_RS06920	1451677..1452486	-	810	WP_000166319.1	recombination protein RecT	-
FQT78_RS06925	1452479..1455079	-	2601	WP_000105152.1	exodeoxyribonuclease VIII	-
FQT78_RS06930	1455181..1455456	-	276	WP_001349884.1	hypothetical protein	-
FQT78_RS06935	1455531..1455701	-	171	WP_001349883.1	hypothetical protein	-
FQT78_RS06940	1455701..1455922	-	222	WP_000560220.1	killing protein KilR	-
FQT78_RS06945	1456343..1456495	-	153	WP_001169153.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1449693..1498549	48856

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T138862 WP_001317028.1 NZ_CP043487:c1451620-1451426 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T138862 NZ_CP043487:c1451620-1451426 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGGTATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT138862 NZ_CP043487:1451249-1451427 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAATTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin