Detailed information of TA system TA138832

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1447186..1447557
• Replicon: chromosome
• Accession: NZ_CP043486
• Organism: Escherichia coli strain SL112

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: FQT94_RS06885
• Protein ID: WP_001317028.1
• Coordinates: 1447363..1447557 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1447186..1447364 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQT94_RS06855	1442529..1443092	+	564	WP_001046821.1	DNA endonuclease SmrA	-
FQT94_RS06860	1443113..1444345	-	1233	WP_001307164.1	diguanylate cyclase DgcM	-
FQT94_RS06865	1444600..1445532	+	933	Protein_1348	zinc transporter ZntB	-
FQT94_RS06870	1445630..1446865	-	1236	WP_000040852.1	site-specific integrase	-
FQT94_RS06875	1446867..1447082	-	216	WP_000079604.1	excisionase XisR	-
FQT94_RS06880	1447161..1447370	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
-	1447186..1447364	+	179	NuclAT_0	-	Antitoxin
-	1447186..1447364	+	179	NuclAT_0	-	Antitoxin
-	1447186..1447364	+	179	NuclAT_0	-	Antitoxin
-	1447186..1447364	+	179	NuclAT_0	-	Antitoxin
FQT94_RS06885	1447363..1447557	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
FQT94_RS06890	1447614..1448423	-	810	WP_000166319.1	recombination protein RecT	-
FQT94_RS06895	1448416..1451016	-	2601	WP_000105152.1	exodeoxyribonuclease VIII	-
FQT94_RS06900	1451118..1451393	-	276	WP_001349884.1	hypothetical protein	-
FQT94_RS06905	1451468..1451638	-	171	WP_001349883.1	hypothetical protein	-
FQT94_RS06910	1451638..1451859	-	222	WP_000560220.1	killing protein KilR	-
FQT94_RS06915	1452280..1452432	-	153	WP_001169153.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1441291..1494486	53195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T138832 WP_001317028.1 NZ_CP043486:c1447557-1447363 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T138832 NZ_CP058236:846200-846628 [Mycobacterium tuberculosis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT138832 NZ_CP043486:1447186-1447364 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAATTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin