Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1978832..1979418 Replicon chromosome
Accession NZ_CP043476
Organism Xanthomonas hyacinthi strain CFBP 1156

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FZ025_RS08885 Protein ID WP_104558372.1
Coordinates 1978832..1979113 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FZ025_RS08890 Protein ID WP_104558371.1
Coordinates 1979128..1979418 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZ025_RS08870 1974797..1974985 + 189 Protein_1730 BlaI/MecI/CopY family transcriptional regulator -
FZ025_RS08875 1975039..1975734 - 696 WP_104558391.1 ribonuclease H-like domain-containing protein -
FZ025_RS08880 1976166..1978661 - 2496 WP_104558373.1 DEAD/DEAH box helicase -
FZ025_RS08885 1978832..1979113 + 282 WP_104558372.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FZ025_RS08890 1979128..1979418 + 291 WP_104558371.1 HigA family addiction module antidote protein Antitoxin
FZ025_RS08895 1979567..1980229 + 663 WP_046980407.1 hemolysin III family protein -
FZ025_RS08900 1980333..1980785 + 453 WP_046980406.1 hypothetical protein -
FZ025_RS08905 1981067..1981486 - 420 WP_046980405.1 BA14K family protein -
FZ025_RS08910 1981640..1981933 - 294 WP_046980404.1 DUF2388 domain-containing protein -
FZ025_RS08915 1982161..1982352 - 192 WP_046980403.1 hypothetical protein -
FZ025_RS08920 1982780..1983007 - 228 WP_046980409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.49 Da        Isoelectric Point: 10.0943

>T138799 WP_104558372.1 NZ_CP043476:1978832-1979113 [Xanthomonas hyacinthi]
VIRNFVDKEAEKIWQGMPSRRLPADIRAVARRKLRMLNSAATLDDLRVPPANRLESLKGDRKGQYSIRINDQWRVCFQWK
DGDALDVEIVDYH

Download         Length: 282 bp

>T138799 NZ_CP043476:1978832-1979113 [Xanthomonas hyacinthi]
GTGATCCGGAACTTTGTCGACAAGGAAGCCGAAAAGATCTGGCAGGGCATGCCTTCCCGGCGATTGCCGGCCGATATCCG
GGCCGTGGCTCGGCGCAAGCTGCGCATGCTCAACAGCGCGGCCACGCTGGACGATCTGCGTGTTCCGCCGGCCAACCGTC
TGGAGTCCTTGAAGGGAGACCGCAAGGGCCAATACAGCATCCGGATCAACGATCAATGGCGCGTGTGCTTCCAATGGAAG
GACGGCGATGCGCTGGACGTGGAAATCGTCGACTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10387.00 Da        Isoelectric Point: 10.0800

>AT138799 WP_104558371.1 NZ_CP043476:1979128-1979418 [Xanthomonas hyacinthi]
MKTLPNIHPGEVLLEEFLTPLGISQNALARAAGVPPRRINEIVLGKRSVTADSAIRLAAALGTSERFWLGLQADYDLEQA
RRALGAQAQKIERIAA

Download         Length: 291 bp

>AT138799 NZ_CP058226:876443-876709 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References