138787

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1972310..1972892 Replicon chromosome
Accession NZ_CP043440
Organism Cupriavidus campinensis strain MJ1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FZF10_RS11050 Protein ID WP_144201665.1
Coordinates 1972614..1972892 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FZF10_RS11045 Protein ID WP_144201663.1
Coordinates 1972310..1972600 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF10_RS11015 1967343..1968301 - 959 Protein_1775 TRAP transporter substrate-binding protein -
FZF10_RS11020 1968451..1969308 - 858 WP_149137568.1 SMP-30/gluconolactonase/LRE family protein -
FZF10_RS11025 1969352..1970188 - 837 WP_149136453.1 NAD(P)-dependent oxidoreductase -
FZF10_RS11030 1970340..1970672 - 333 WP_149136454.1 hypothetical protein -
FZF10_RS11035 1970872..1971939 + 1068 WP_149136455.1 porin -
FZF10_RS11045 1972310..1972600 - 291 WP_144201663.1 HigA family addiction module antidote protein Antitoxin
FZF10_RS11050 1972614..1972892 - 279 WP_144201665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FZF10_RS11055 1973291..1973737 - 447 WP_187645083.1 response regulator transcription factor -
FZF10_RS11060 1973927..1975540 - 1614 WP_149136456.1 FapA family protein -
FZF10_RS11065 1975802..1976644 + 843 WP_149136457.1 SAM-dependent methyltransferase -
FZF10_RS11070 1976680..1977282 - 603 WP_149136458.1 DUF1415 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10419.99 Da        Isoelectric Point: 9.8292

>T138787 WP_144201665.1 NZ_CP043440:c1972892-1972614 [Cupriavidus campinensis]
MIRSFAHKGLERFFTTGSTAAIPAMHVKRLRLILALLDEAGSARDMDAPGLRLHALKGDRAELWAVTVQANWRVTFRFEN
GDAHIVNYIDYH

Download         Length: 279 bp

>T138787 NZ_CP058223:c3685884-3685708 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10779.31 Da        Isoelectric Point: 6.2194

>AT138787 WP_144201663.1 NZ_CP043440:c1972600-1972310 [Cupriavidus campinensis]
MRMHNPPHPGELLAELWLEPLRLTITDTAAALDVSRKTVSEIVNGRAGVTPEMAVRLELAFGKSAESWLAHQAAYDLWQV
DQYRSELRVRSLQPAT

Download         Length: 291 bp

>AT138787 NZ_CP043440:c1972600-1972310 [Cupriavidus campinensis]
ATGCGCATGCACAATCCACCGCATCCGGGCGAGTTGCTTGCGGAGCTTTGGCTCGAGCCGCTGCGGCTGACGATTACCGA
TACCGCCGCGGCGCTCGATGTTTCGCGGAAGACGGTTTCCGAGATCGTGAATGGCCGGGCTGGCGTCACGCCGGAGATGG
CGGTTCGGCTTGAACTGGCGTTCGGCAAGAGCGCCGAGTCTTGGCTCGCGCATCAGGCCGCGTACGACCTGTGGCAGGTG
GACCAGTACCGCAGCGAGCTGCGCGTGCGCTCGCTCCAGCCCGCGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References