Detailed information of TA system TA138688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 2583437..2583849
• Replicon: chromosome
• Accession: NZ_CP043406
• Organism: Escherichia coli strain NMBU-W13E19

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: FZN32_RS12720
• Protein ID: WP_000132601.1
• Coordinates: 2583437..2583778 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	2583773..2583849 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN32_RS12710	2580850..2581896	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
FZN32_RS12715	2581896..2583275	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
FZN32_RS12720	2583437..2583778	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
-	2583773..2583849	+	77	NuclAT_12	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_12	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_12	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_12	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_13	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_13	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_13	-	Antitoxin
-	2583773..2583849	+	77	NuclAT_13	-	Antitoxin
FZN32_RS12725	2584006..2585400	-	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
FZN32_RS12730	2585397..2586986	-	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2571154..2585400	14246

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T138688 WP_000132601.1 NZ_CP043406:c2583778-2583437 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T138688 NZ_CP058209:2199689-2199898 [Escherichia marmotae]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT138688 NZ_CP043406:2583773-2583849 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin