Detailed information of TA system TA138686

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2468216..2468474
• Replicon: chromosome
• Accession: NZ_CP043406
• Organism: Escherichia coli strain NMBU-W13E19

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: FZN32_RS12170
• Protein ID: WP_000935262.1
• Coordinates: 2468265..2468474 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2468216..2468273 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZN32_RS12155	2464608..2465567	+	960	WP_000871674.1	hypothetical protein	-
FZN32_RS12160	2465605..2466504	-	900	WP_001300855.1	transcriptional activator NhaR	-
FZN32_RS12165	2466570..2467736	-	1167	WP_137456289.1	Na+/H+ antiporter NhaA	-
-	2468216..2468273	-	58	-	-	Antitoxin
FZN32_RS12170	2468265..2468474	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
FZN32_RS12175	2468578..2469708	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
FZN32_RS12180	2469797..2471713	-	1917	WP_000516135.1	molecular chaperone DnaK	-
FZN32_RS12185	2472089..2472493	+	405	WP_000843584.1	DUF2541 family protein	-
FZN32_RS12190	2472519..2473232	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T138686 WP_000935262.1 NZ_CP043406:2468265-2468474 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T138686 NZ_CP058209:1070482-1070760 [Escherichia marmotae]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGATCTAGATGATATAACTAGCTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT138686 NZ_CP043406:c2468273-2468216 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin