Detailed information of TA system TA138666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 996555..997067
• Replicon: chromosome
• Accession: NZ_CP043405
• Organism: Streptococcus ratti strain ATCC 31377

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FY406_RS04865
• Protein ID: WP_003086504.1
• Coordinates: 996813..997067 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: M7E034
• Locus tag: FY406_RS04860
• Protein ID: WP_003090931.1
• Coordinates: 996555..996809 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY406_RS04835	991964..992701	+	738	WP_003086515.1	class I SAM-dependent methyltransferase	-
FY406_RS04840	992801..993484	+	684	WP_003086513.1	hypothetical protein	-
FY406_RS04845	993706..994257	+	552	WP_081498705.1	Fic family protein	-
FY406_RS04850	994254..995351	+	1098	WP_003086510.1	nucleotidyltransferase	-
FY406_RS04855	995358..996218	+	861	WP_003086508.1	hypothetical protein	-
FY406_RS04860	996555..996809	+	255	WP_003090931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FY406_RS04865	996813..997067	+	255	WP_003086504.1	Txe/YoeB family addiction module toxin	Toxin
FY406_RS04870	997382..998098	+	717	WP_003086502.1	MerR family transcriptional regulator	-
FY406_RS04875	998241..998651	+	411	WP_003086500.1	peptide deformylase	-
FY406_RS04880	998721..999437	+	717	WP_003086498.1	YebC/PmpR family DNA-binding transcriptional regulator	-
FY406_RS04885	999630..999974	+	345	WP_003086495.1	thiol reductase thioredoxin	-
FY406_RS04890	1000082..1000447	+	366	WP_003086494.1	preprotein translocase subunit YajC	-
FY406_RS04895	1000580..1001695	+	1116	WP_003086492.1	ISAs1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1000580..1001695	1115

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10096.45 Da
• Isoelectric Point: 7.9815

>T138666 WP_003086504.1 NZ_CP043405:996813-997067 [Streptococcus ratti]
MLLTFTDDAWNDYCYWQGQDRKTLKRINKIIKDIQRNPFTGIGKPEPLKYDFQGAWSRRIDAENRIIYMVDNDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T138666 NZ_CP043405:996813-997067 [Streptococcus ratti]
ATGTTATTAACCTTTACGGATGATGCTTGGAATGATTATTGTTACTGGCAGGGACAGGATCGTAAGACCTTGAAACGTAT
TAACAAGATTATTAAGGATATTCAGCGCAACCCTTTTACTGGAATTGGAAAACCTGAGCCATTGAAATATGACTTTCAAG
GTGCCTGGTCACGGCGAATCGATGCAGAGAATCGTATTATCTATATGGTTGATAACGATAGTGTCGCCTTTTTATCTTTT
AAAGATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9705.01 Da
• Isoelectric Point: 4.8430

>AT138666 WP_003090931.1 NZ_CP043405:996555-996809 [Streptococcus ratti]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNQELSDKVLRGMAQVKSGAVKVH
QIEE

Nucleotide

• Length: 255 bp

>AT138666 NZ_CP058198:78558-78776 [Enterobacter roggenkampii]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Antitoxin

• AlphaFold DB: M7E034