Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1140746..1141395 Replicon chromosome
Accession NZ_CP043398
Organism Leclercia adecarboxylata strain G426

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FY047_RS05290 Protein ID WP_103791861.1
Coordinates 1141033..1141395 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FY047_RS05285 Protein ID WP_059308573.1
Coordinates 1140746..1141045 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY047_RS05275 1137142..1139115 + 1974 WP_032616918.1 PhoX family phosphatase -
FY047_RS05280 1139219..1140604 + 1386 WP_077226217.1 phenylalanine transporter -
FY047_RS05285 1140746..1141045 - 300 WP_059308573.1 helix-turn-helix transcriptional regulator Antitoxin
FY047_RS05290 1141033..1141395 - 363 WP_103791861.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY047_RS05295 1141672..1142913 + 1242 WP_032616942.1 MFS transporter -
FY047_RS05300 1142925..1143950 + 1026 WP_103791862.1 sugar phosphate isomerase/epimerase -
FY047_RS05305 1143943..1145085 + 1143 WP_077226215.1 Gfo/Idh/MocA family oxidoreductase -
FY047_RS05310 1145161..1146141 + 981 WP_103791863.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13887.78 Da        Isoelectric Point: 6.0839

>T138645 WP_103791861.1 NZ_CP043398:c1141395-1141033 [Leclercia adecarboxylata]
MWEVETTDTFDKWFNHQTQALKEDVLAIMHILSEYGPQLGRPWVDTVKNSHYANMKELRIQHAGDPVRAFFAFDPGCKGI
ILCAGNKTGKNEKRFYKDMITIADAEFSDYLASKEAEWLR

Download         Length: 363 bp

>T138645 NZ_CP058187:c4710937-4710566 [Enterobacter hormaechei]
ATGGAGCACATGGCTGTGTTTGACACCAATATCCTCATCGATCTTTTTAATAACCACGTTGAGGCTGCGGATGCGATCGA
TCGCACAGCTTCGCATCGTGCCATTAGCCTCATCACATGGATGGAAGTAATGGTGGGCGCTCGCAGGCACGGTCAAGAAG
CAAAAACGGCAGCCGTGATGGAGGCCTTTGAAATTATTGATATAACAAGGGAAATTGCTGAAAGAAGCGTATTACTTCGC
GAACAGCACGGGATGAAGCTTCCTGACGCCATTATTCTGGCTACTGCTCAGAGCAGAAGCTGTCCGTTAATTTCGCGCAA
TACGAAAGACTTTTCGGGTATTGCTGGGGTCGTTTCACCTTACCACCTGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10972.68 Da        Isoelectric Point: 5.8526

>AT138645 WP_059308573.1 NZ_CP043398:c1141045-1140746 [Leclercia adecarboxylata]
MATLKELMAQQSQESQERIAAKVEDLRIIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHF

Download         Length: 300 bp

>AT138645 NZ_CP058187:c4711182-4710940 [Enterobacter hormaechei]
ATGAGTCTTTTGGCGGACCTTACTATGGGCAGAATACTGATCGATTTGTCTGATGACGTGATTCAACGACTGGATAACCT
GAAGCAGTTGCGCAACCGGCCGCGCGCCGAACTGCTGCGGGAAGCCATAGAACTGTATCTCGACCAGCAGAATTCATCGG
TTATCCGCGAAGCGCTTGGCCTGTGGGGAAATCAGCAGGAAGATGGGCTTGAGTACGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References