Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1212956..1213605 Replicon chromosome
Accession NZ_CP043397
Organism Leclercia adecarboxylata strain L21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FY044_RS05825 Protein ID WP_077226216.1
Coordinates 1213243..1213605 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FY044_RS05820 Protein ID WP_059308573.1
Coordinates 1212956..1213255 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY044_RS05810 1209352..1211325 + 1974 WP_032616918.1 PhoX family phosphatase -
FY044_RS05815 1211429..1212814 + 1386 WP_077226217.1 phenylalanine transporter -
FY044_RS05820 1212956..1213255 - 300 WP_059308573.1 helix-turn-helix transcriptional regulator Antitoxin
FY044_RS05825 1213243..1213605 - 363 WP_077226216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FY044_RS05830 1213882..1215123 + 1242 WP_077226245.1 MFS transporter -
FY044_RS05835 1215135..1216160 + 1026 WP_059308572.1 sugar phosphate isomerase/epimerase -
FY044_RS05840 1216153..1217295 + 1143 WP_077226215.1 Gfo/Idh/MocA family oxidoreductase -
FY044_RS05845 1217371..1218351 + 981 WP_032616924.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14014.03 Da        Isoelectric Point: 7.3565

>T138632 WP_077226216.1 NZ_CP043397:c1213605-1213243 [Leclercia adecarboxylata]
MWEVETTDTFDKWFNHQTQALKEDVLAIMHILSEYGPQLGRPWVDTVKNSHYANMKELRIQHAGDPVRAFFAFDPVRKAI
ILCAGNKTGKNEKRFYKDMITMADAEFSDYLASKEAKWLR

Download         Length: 363 bp

>T138632 NZ_CP043397:c1213605-1213243 [Leclercia adecarboxylata]
ATGTGGGAAGTCGAAACAACGGATACGTTTGACAAGTGGTTTAACCACCAGACACAAGCCTTGAAAGAAGATGTCCTGGC
TATAATGCATATCCTCTCAGAGTACGGTCCACAGCTGGGCCGTCCCTGGGTCGATACAGTTAAAAACTCACATTACGCGA
ATATGAAAGAGCTACGCATTCAGCATGCAGGGGATCCGGTTCGTGCTTTTTTTGCCTTCGATCCTGTTCGTAAAGCCATA
ATTTTATGTGCTGGAAATAAGACGGGAAAAAATGAAAAGCGATTCTATAAAGATATGATCACCATGGCTGATGCTGAATT
CAGCGATTATCTGGCGAGTAAGGAGGCCAAATGGCTACGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10972.68 Da        Isoelectric Point: 5.8526

>AT138632 WP_059308573.1 NZ_CP043397:c1213255-1212956 [Leclercia adecarboxylata]
MATLKELMAQQSQESQERIAAKVEDLRIIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHF

Download         Length: 300 bp

>AT138632 NZ_CP058180:2083479-2083781 [Klebsiella grimontii]
ATGGGCAGAACGCTGGAACAGCTGATGGCGGATGAAAAACCGGAAGTCGTGGCTGACGCCCGGGCTATGGCGGCGGACAT
CCTGCTCAACATTCACCTTGCAGAACTGCGTGAGAAAGTACAGAAAACGCAGGTCGAAATGGCGCAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGCATGGAAAAACCAGGCCGTGACCTGAAGCTTTCCACGCTTAAACGCTACGTTGAAGCCACC
GGCGGCAAGCTACGTCTTGATGTTGAGTTGCCAGATGGTTCTCACTACGGATTTGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References