Detailed information of TA system TA138617

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2561151..2561335
• Replicon: chromosome
• Accession: NZ_CP043392
• Organism: Staphylococcus aureus strain NRS384-rpoB-H481N-NCV

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: FZC50_RS13215
• Protein ID: WP_000482650.1
• Coordinates: 2561228..2561335 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2561151..2561211 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FZC50_RS13200	2556681..2556848	-	168	WP_001790576.1	hypothetical protein	-
FZC50_RS13205	2557079..2558812	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
FZC50_RS13210	2558837..2560600	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	2561151..2561211	+	61	-	-	Antitoxin
FZC50_RS13215	2561228..2561335	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
FZC50_RS13220	2561469..2561855	-	387	WP_000779358.1	flippase GtxA	-
FZC50_RS13225	2562123..2563265	+	1143	WP_001176863.1	glycerate kinase	-
FZC50_RS13230	2563325..2563984	+	660	WP_000831298.1	membrane protein	-
FZC50_RS13235	2564166..2565377	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
FZC50_RS13240	2565500..2565973	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T138617 WP_000482650.1 NZ_CP043392:c2561335-2561228 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T138617 NZ_CP058172:c1085168-1084950 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAGCGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT138617 NZ_CP043392:2561151-2561211 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin