Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2535803..2536320 Replicon chromosome
Accession NZ_CP043392
Organism Staphylococcus aureus strain NRS384-rpoB-H481N-NCV

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FZC50_RS13075 Protein ID WP_000113262.1
Coordinates 2535803..2536069 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag FZC50_RS13080 Protein ID WP_000584502.1
Coordinates 2536069..2536320 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZC50_RS13045 2531229..2531765 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FZC50_RS13050 2531998..2532822 - 825 WP_000572040.1 formate/nitrite transporter family protein -
FZC50_RS13055 2533039..2533221 - 183 WP_000230294.1 hypothetical protein -
FZC50_RS13060 2533305..2533772 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FZC50_RS13065 2533958..2535508 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FZC50_RS13070 2535697..2535768 - 72 Protein_2472 hypothetical protein -
FZC50_RS13075 2535803..2536069 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FZC50_RS13080 2536069..2536320 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FZC50_RS13085 2536485..2536586 - 102 WP_001791744.1 hypothetical protein -
FZC50_RS13090 2536593..2537192 - 600 WP_000162813.1 DsbA family protein -
FZC50_RS13095 2537211..2537570 - 360 WP_000819847.1 DUF4467 domain-containing protein -
FZC50_RS13100 2537825..2539075 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
FZC50_RS13105 2539172..2539903 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FZC50_RS13110 2539900..2540619 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T138616 WP_000113262.1 NZ_CP043392:c2536069-2535803 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T138616 NZ_CP058172:28762-29076 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAATACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT138616 WP_000584502.1 NZ_CP043392:c2536320-2536069 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT138616 NZ_CP058172:29073-29492 [Enterobacter hormaechei]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCATGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGCCCCTTGCTGGATATTGTTT
GCGCCAGAATTAGCCATTACGAAGCTAATCGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGA
ATTGCAGTTTTGAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACTCTGAACCATATTAAAAAGCTGGCGGTCAGATTTGGGGTATCAC
CTGCGCTATTTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References